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Gene Expression Data
Assay Details
Assay
Reference: J:192361 Srinivasan K, et al., A network of genetic repression and derepression specifies projection fates in the developing neocortex. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19071-8
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7620322
Gene symbol: Fezf2
Gene name: Fez family zinc finger 2
Reporter: alkaline phosphatase
Antibody: anti-PLAP
Results
Specimen 6K: postnatal; Fezf2tm1Skm/Fezf2+ (more )
Structure Level Pattern Image Note
TS28: corpus striatum Strong 6K
TS28: thalamus Strong 6K
Specimen 6L: postnatal; Fezf2tm1Skm/Fezf2+, Satb2tm1Rug/Satb2tm1Rug (more )
Structure Level Pattern Image Note
TS28: corpus striatum Weak 6L Satb2 mutants show a reduction in PLAP+ axons traversing the striatum.
TS28: thalamus Trace 6L There was almost no expression in the thalamus of the mutant.
Specimen 6M: postnatal; Fezf2tm1Skm/Fezf2tm1Skm (more )
Structure Level Pattern Image Note
TS28: anterior commissure Strong 6M
TS28: corpus striatum Strong 6M
TS28: thalamus Strong 6M
Specimen 6N: postnatal; Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm1Rug (more )
Structure Level Pattern Image Note
TS28: corpus striatum Weak 6N Reporter staining was reduced in the striatum and thalamus of the mutant.
TS28: thalamus Weak 6N Reporter staining was reduced in the striatum and thalamus of the mutant.
TS28: anterior commissure Strong 6N Staining remained robust in the anterior commissure.
Specimen 6O: postnatal; Bcl11btm1Jpk/Bcl11btm1Jpk, Fezf2tm1Skm/Fezf2+ (more )
Structure Level Pattern Image Note
TS28: corpus striatum Strong 6O
TS28: thalamus Strong 6O
Specimen S3B: postnatal; Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm1Rug (more )
Note: Double labeled: red - Fezf2 reporter; green - Satb2 reporter (assay MGI:7620184).
Structure Level Pattern Image Note
TS28: cerebral peduncle Present S3C , S3B Robust PLAP+ axons extend through the striatum, thalamus, and along the cerebral peduncle, heading toward the pons.
TS28: corpus striatum Present S3C , S3B Robust PLAP+ axons extend through the striatum, thalamus, and along the cerebral peduncle, heading toward the pons.
TS28: thalamus Present S3C , S3B Robust PLAP+ axons extend through the striatum, thalamus, and along the cerebral peduncle, heading toward the pons.
Specimen S3D: postnatal; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant. Double labeled: red - Fezf2 reporter; green - Satb2 reporter (assay MGI:7620184).
Structure Level Pattern Image Note
TS28: cerebral peduncle Present S3D
TS28: thalamus Absent S3D
Specimen S3E: postnatal; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant. Double labeled: red - Fezf2 reporter; green - Satb2 reporter (assay MGI:7620184).
Structure Level Pattern Image Note
TS28: cerebral peduncle Present S3E , S3F
Specimen S3G: postnatal; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant. Double labeled: red - Fezf2 reporter; green - Satb2 reporter (assay MGI:7620184).
Structure Level Pattern Image Note
TS28: telencephalon Present Regionally restricted S3G PLAP+ axons fail to project past the striatum.
Specimen S3H: postnatal; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant. Double labeled: red - Fezf2 reporter; green - Satb2 reporter (assay MGI:7620184).
Structure Level Pattern Image Note
TS28: telencephalon Present Regionally restricted S3H PLAP+ axons fail to project past the striatum.
Specimen S3I: postnatal; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant. Double labeled: red - Fezf2 reporter; green - Satb2 reporter (assay MGI:7620184).
Structure Level Pattern Image Note
TS28: telencephalon Present Regionally restricted S3I Axons positive for both beta-gal and PLAP were observed medial to the striatum in anterior sections.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory