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Rr474em2Mbu
Endonuclease-mediated Allele Detail
Summary
Symbol: Rr474em2Mbu
Name: regulatory region 474; endonuclease-mediated mutation 2, Meinrad Busslinger
MGI ID: MGI:7620307
Synonyms: WapldeltaP1,P2
Gene: Rr474  Location: unknown  Genetic Position: Chr14, Syntenic
Alliance: Rr474em2Mbu page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Modified regulatory region)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR-targeting deleted 339 bp encompassing the second Pax5 binding site down stream of the coding sequence. (J:294166)
Inheritance:    Not Specified
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr474 Mutation:  0 strains or lines available
Notes
This allele was generated in conjunction with Rr473em2Mbo.
References
Original:  J:294166 Hill L, et al., Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion. Nature. 2020 Aug;584(7819):142-147
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory