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Gene Expression Data
Assay Details
Assay
Reference: J:192361 Srinivasan K, et al., A network of genetic repression and derepression specifies projection fates in the developing neocortex. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19071-8
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7620184
Gene symbol: Satb2
Gene name: special AT-rich sequence binding protein 2
Reporter: lacZ
Antibody: anti-B-galactosidase (Abcam)
Results
Specimen 1A: postnatal day 0; Satb2tm1Rug/Satb2tm2Rug (more )
Structure Level Pattern Image Note
TS27: corticospinal tract Absent 1A No staining was seen in the pyramidal tract.
Specimen 1B: postnatal day 0; Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: corticospinal tract Present Regionally restricted 1B Aberrant expression was detected in the pyramidal tract.
Specimen 1C: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: corticospinal tract Absent 1C No staining was seen in the pyramidal tract.
Specimen 1D: postnatal day 0; Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: nerve fiber tract Present Regionally restricted 1D The majority of beta-gal+ callosal axons in Satb2 conditional mutants fail to project across the corpus callosum at P0. Instead, these axons project sub-cerebrally into the cerebral peduncle and thalamus.
TS27: cerebral peduncle Present 1D
TS27: thalamus Present 1D
Specimen 1E: postnatal day 0; Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebral peduncle Present Regionally restricted 1E Beta-gal+ aberrant callosal axons project sub-cerebrally into the cerebral peduncle.
Specimen 1F: postnatal day 0; Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebral peduncle Present 1F Beta-gal+ aberrant callosal axons project sub-cerebrally into the cerebral peduncle and thalamus.
TS27: thalamus Present 1F Beta-gal+ aberrant callosal axons project sub-cerebrally into the cerebral peduncle and thalamus.
Specimen 1G: postnatal day 0; Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: corticospinal tract Present Regionally restricted 1G A small number of beta-gal+ axons were observed in the pyramidal tract.
Specimen 1H: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Satb2tm1Rug/Satb2+ (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present 1H
Specimen 1I: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: corpus callosum Present 1I
Specimen 1J: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: corpus striatum Present Regionally restricted 1J Defasciculated beta-gal+ axons descend subcortically into the striatum.
Specimen 1K: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebral peduncle Present 1K Defasciculated beta-gal+ axons were observed along the cerebral peduncle.
Specimen 1L: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebral peduncle Present 1L Defasciculated beta-gal+ axons were observed along the cerebral peduncle.
Specimen 1M: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: corticospinal tract Absent 1M Defasciculated beta-gal+ axons were not observed in the pyramidal tract.
Specimen 1N: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Satb2tm1Rug/Satb2tm1Rug (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present 1N
Specimen 2K: postnatal day 4; Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm1Rug (more )
Note: Double labeled: green - Satb2 reporter; red - Fezf2 reporter (assay MGI:7620251).
Structure Level Pattern Image Note
TS28: nerve fiber tract Present Regionally restricted 2K Callosal axons in double mutants fail to project across the corpus callosum at P0.
Specimen S2A: postnatal day 0; Satb2tm1Rug/Satb2+ (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present S2A
Specimen S2B: postnatal day 0; Satb2tm1Rug/Satb2+ (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present S2B
Specimen S2C: postnatal day 0; Satb2tm1Rug/Satb2tm1Rug (more )
Structure Level Pattern Image Note
TS27: cerebral peduncle Present S2C Callosal axons in the mutant extend axons through the striatum and into the thalamus and cerebral peduncle.
TS27: corpus striatum Present S2C Callosal axons in the mutant extend axons through the striatum and into the thalamus and cerebral peduncle.
TS27: thalamus Present S2C Callosal axons in the mutant extend axons through the striatum and into the thalamus and cerebral peduncle.
Specimen S2D: postnatal day 0; Satb2tm1Rug/Satb2tm1Rug (more )
Structure Level Pattern Image Note
TS27: cerebral peduncle Present S2D Callosal axons aberrantly extend axons through the striatum and into the thalamus and cerebral peduncle.
TS27: corpus striatum Present S2D Callosal axons aberrantly extend axons through the striatum and into the thalamus and cerebral peduncle.
TS27: thalamus Present S2D Callosal axons aberrantly extend axons through the striatum and into the thalamus and cerebral peduncle.
Specimen S2E: postnatal day 0; Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2+ (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present S2E
Specimen S2F: postnatal day 0; Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2+ (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present S2F
Specimen S2G: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Satb2tm1Rug/Satb2+ (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present S2G
Specimen S2H: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Satb2tm1Rug/Satb2+ (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present S2H
Specimen S2I: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2+ (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present S2I
Specimen S2J: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2+ (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present S2J
Specimen S2K: postnatal day 0; Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm1Rug (more )
Structure Level Pattern Image Note
TS27: cerebral peduncle Present S2K Beta-gal+ axons in the mutant extend axons through the striatum and into the thalamus and cerebral peduncle.
TS27: corpus striatum Present S2K Beta-gal+ axons in the mutant extend axons through the striatum and into the thalamus and cerebral peduncle.
TS27: thalamus Present S2K Beta-gal+ axons in the mutant extend axons through the striatum and into the thalamus and cerebral peduncle.
Specimen S2L: postnatal day 0; Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm1Rug (more )
Structure Level Pattern Image Note
TS27: cerebral peduncle Present S2L Beta-gal+ axons in the mutant extend subcerebrally to the striatum.
TS27: thalamus Present S2L Beta-gal+ axons in the mutant extend subcerebrally to the striatum.
Specimen S2M: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Satb2tm1Rug/Satb2tm1Rug (more )
Structure Level Pattern Image Note
TS27: cerebral peduncle Present S2M Beta-gal+ axons in the mutant extend subcerebrally to the striatum and into the cerebral peduncle.
TS27: corpus striatum Present S2M Beta-gal+ axons in the mutant extend subcerebrally to the striatum and into the cerebral peduncle.
Specimen S2N: postnatal day 0; Bcl11btm1Jpk/Bcl11btm1Jpk, Satb2tm1Rug/Satb2tm1Rug (more )
Structure Level Pattern Image Note
TS27: cerebral peduncle Present S2N Beta-gal+ axons in the mutant extend subcerebrally to the striatum and into the cerebral peduncle.
Specimen S2O: postnatal day 0; Satb2tm1Rug/Satb2+ (more )
Structure Level Pattern Image Note
TS27: corpus callosum Present S2O
Specimen S2P: postnatal day 0; Satb2tm1Rug/Satb2tm1Rug (more )
Structure Level Pattern Image Note
TS27: thalamus Present S2P Beta-gal+ axons project inappropriately to the thalamus.
Specimen S3A: postnatal; Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm1Rug (more )
Note: Double labeled: green - Satb2 reporter; red - Fezf2 reporter (assay MGI:7620322).
Structure Level Pattern Image Note
TS28: cerebral peduncle Present S3A , S3C Beta-gal+ axons in the mutant extend axons through the striatum and into the thalamus and and along the cerebral peduncle, heading toward the pons.
TS28: corpus striatum Present S3A , S3C Beta-gal+ axons in the mutant extend axons through the striatum and into the thalamus and and along the cerebral peduncle, heading toward the pons.
TS28: thalamus Present S3A , S3C Beta-gal+ axons in the mutant extend axons through the striatum and into the thalamus and and along the cerebral peduncle, heading toward the pons.
Specimen S3D: postnatal; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant. Double labeled: green - Satb2 reporter; red - Fezf2 reporter (assay MGI:7620322).
Structure Level Pattern Image Note
TS28: cerebral peduncle Present S3D
TS28: thalamus Absent S3D
Specimen S3F: postnatal; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2+, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant. Double labeled: green - Satb2 reporter; red - Fezf2 reporter (assay MGI:7620322).
Structure Level Pattern Image Note
TS28: cerebral peduncle Present S3F
Specimen S3G: postnatal; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant. Double labeled: green - Satb2 reporter; red - Fezf2 reporter (assay MGI:7620322).
Structure Level Pattern Image Note
TS28: cerebral peduncle Present S3G
TS28: thalamus Present S3G
Specimen S3H: postnatal; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant. Double labeled: green - Satb2 reporter; red - Fezf2 reporter (assay MGI:7620322).
Structure Level Pattern Image Note
TS28: corpus striatum Present S3H
Specimen S3I: postnatal; Bcl11btm1Jpk/Bcl11btm1Jpk, Emx1tm1(cre)Krj/Emx1+, Fezf2tm1Skm/Fezf2tm1Skm, Satb2tm1Rug/Satb2tm2Rug (more )
Note: Conditional mutant. Double labeled: green - Satb2 reporter; red - Fezf2 reporter (assay MGI:7620322).
Structure Level Pattern Image Note
TS28: telencephalon Present Regionally restricted S3I Axons positive for both beta-gal and PLAP were observed medial to the striatum in anterior sections.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory