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Gene Expression Data
Assay Details
Assay
Reference: J:302618 Wang B, et al., The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Autophagy. 2018;14(5):796-811
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7616424
Gene symbol: Sqstm1
Gene name: sequestosome 1
Antibody: anti-SQSTM1 (M01), clone 2C11 (H00008878-M01)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2E control: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Ambiguous 2E control Trace or absent steady-state level.
Specimen 2E Ulk1/2-cDKO: postnatal day 0; Tg(Nes-cre)1Kln/0, Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1Thsn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebral cortex Ambiguous 2E Ulk1/2-cDKO Trace or absent steady-state level, similar as in the control.
Specimen 2E Atg7-cKO: postnatal day 0; Atg7tm1Tchi/Atg7tm1Tchi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebral cortex Strong 2E Atg7-cKO Dramatically increased expression compared with the control.
Specimen 2E Rb1cc1-cKO: postnatal day 0; Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebral cortex Present 2E Rb1cc1-cKO Dramatically increased expression compared with the control.
Specimen 2F control: postnatal day 21 (more )
Note: Double labeled: red - Sqstm1; green - ubiquitin.
Structure Level Pattern Image Note
TS28: cerebral cortex Ambiguous 2F control Trace or absent steady-state level.
Specimen 2F Ulk1/2-cDKO: postnatal day 21; Tg(Nes-cre)1Kln/0, Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1Thsn (more )
Note: Conditional mutant. Double labeled: red - Sqstm1; green - ubiquitin.
Structure Level Pattern Image Note
TS28: cerebral cortex Ambiguous 2F Ulk1/2-cDKO Trace or absent steady-state level, similar as in the control.
Specimen 2F Atg7-cKO: postnatal day 21; Atg7tm1Tchi/Atg7tm1Tchi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: red - Sqstm1; green - ubiquitin.
Structure Level Pattern Image Note
TS28: cerebral cortex Strong 2F Atg7-cKO Accumulation of SQSTM1+ and ubiquitin+ deposits was seen.
Specimen 2F Rb1cc1-cKO: postnatal day 21; Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: red - Sqstm1; green - ubiquitin.
Structure Level Pattern Image Note
TS28: cerebral cortex Present 2F Rb1cc1-cKO Accumulation of SQSTM1+ and ubiquitin+ deposits was seen.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory