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Gene Expression Data
Assay Details
Assay
Reference: J:302618 Wang B, et al., The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Autophagy. 2018;14(5):796-811
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7616374
Gene symbol: Chl1
Gene name: cell adhesion molecule L1-like
Antibody: Anti-Neural Cell Adhesion Molecule L1, clone 324 (MAB5272)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 1A 1/1': embryonic day 18.5 (more )
Note: Rostral region.
Structure Level Pattern Image Note
TS26: corpus callosum Present 1A1/1'
Specimen 1A 2/2': embryonic day 18.5 (more )
Note: Middle region.
Structure Level Pattern Image Note
TS26: anterior commissure Present 1A2/2'
TS26: hippocampal commissure Present 1A2/2'
Specimen 1A 3/3': embryonic day 18.5 (more )
Note: Caudal region.
Structure Level Pattern Image Note
TS26: forebrain Present 1A3/3' The corticothalamic and thalamocortical axons formed a parallel fan-like structure crossing the pallial-subpallial boundary.
Specimen 1A 4/4': embryonic day 18.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn (more )
Note: Rostral region.
Structure Level Pattern Image Note
TS26: corpus callosum Present 1A4/4' Similar as in the wild-type.
Specimen 1A 5/5': embryonic day 18.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn (more )
Note: Middle region.
Structure Level Pattern Image Note
TS26: anterior commissure Present 1A5/5' Similar as in the wild-type.
TS26: hippocampal commissure Present 1A5/5' Similar as in the wild-type.
Specimen 1A 6/6': embryonic day 18.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn (more )
Note: Caudal region.
Structure Level Pattern Image Note
TS26: forebrain Present 1A6/6' Similar as in the wild-type.
Specimen 1A 7/7': embryonic day 18.5; Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Note: Rostral region.
Structure Level Pattern Image Note
TS26: corpus callosum Present 1A7/7' Similar as in the wild-type.
Specimen 1A 8/8': embryonic day 18.5; Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Note: Middle region.
Structure Level Pattern Image Note
TS26: anterior commissure Present 1A8/8' Similar as in the wild-type.
TS26: hippocampal commissure Present 1A8/8' Similar as in the wild-type.
Specimen 1A 9/9': embryonic day 18.5; Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Note: Caudal region.
Structure Level Pattern Image Note
TS26: forebrain Present 1A9/9' Similar as in the wild-type.
Specimen 1A 10/10': embryonic day 18.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Note: Rostral region.
Structure Level Pattern Image Note
TS26: corpus callosum Present 1A10/10' The corpus callosum was thinner compared to that in littermate controls, and many of the callosal axons were overfasciculated.
Specimen 1A 11/11': embryonic day 18.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Note: Middle region.
Structure Level Pattern Image Note
TS26: anterior commissure Present 1A11/11' Severely hypoplastic, compared with the control.
TS26: hippocampal commissure Present 1A11/11' Similar as in the control.
Specimen 1A 12/12': embryonic day 18.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Note: Caudal region.
Structure Level Pattern Image Note
TS26: forebrain Present Regionally restricted 1A12/12' Mutant corticothalamic and thalamocortical axons were disorganized, overfasciculated, and traversed the pallial-subpallial boundary more anteroventrally than axons in littermate controls.
Specimen 1C control: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forebrain Present Regionally restricted 1C control Expressed in the corticothalamic and thalamocortical axons.
Specimen 1C DKO: embryonic day 14.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Structure Level Pattern Image Note
TS22: forebrain Present Regionally restricted 1C DKO Fewer corticothalamic and thalamocortical axons were crossing the pallial-subpallial boundary compared with that in littermate controls.
Specimen 3 control Rostral: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: forebrain Present 3-1 The corticothalamic and thalamocortical axons formed a parallel fan-like structure crossing the pallial-subpallial boundary.
Specimen 3 control Middle: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: anterior commissure Present 3-2
TS27: corpus callosum Present 3-2
TS27: hippocampal commissure Present 3-2
Specimen 3 control Caudal: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: cerebral internal capsule Present 3-3
TS27: external capsule Present 3-3
Specimen 3 Ulk1/2-cDKO Rostral: postnatal day 1; Tg(Nes-cre)1Kln/0, Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1Thsn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: forebrain Present 3-4 Disruption of corticothalamic and thalamocortical axons was seen.
Specimen 3 Ulk1/2-cDKO Middle: postnatal day 1; Tg(Nes-cre)1Kln/0, Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1Thsn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: corpus callosum Present 3-5 Dysgenesis was seen.
TS27: anterior commissure Present 3-5 Hypoplastic anterior commissure was seen.
TS27: hippocampal commissure Present 3-5 Similar as in the control.
Specimen 3 Ulk1/2-cDKO Caudal: postnatal day 1; Tg(Nes-cre)1Kln/0, Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1Thsn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebral internal capsule Present 3-6
TS27: external capsule Present 3-6
Specimen 3 Atg7-cKO Rostral: postnatal day 1; Atg7tm1Tchi/Atg7tm1Tchi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: forebrain Present 3-7 Similar as in the control.
Specimen 3 Atg7-cKO Middle: postnatal day 1; Atg7tm1Tchi/Atg7tm1Tchi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: anterior commissure Present 3-8 Similar as in the control.
TS27: corpus callosum Present 3-8 Similar as in the control.
TS27: hippocampal commissure Present 3-8 Similar as in the control.
Specimen 3 Atg7-cKO Caudal: postnatal day 1; Atg7tm1Tchi/Atg7tm1Tchi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebral internal capsule Present 3-9 Similar as in the control.
TS27: external capsule Present 3-9 Similar as in the control.
Specimen 3 Rb1cc1-cKO Rostral: postnatal day 1; Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: forebrain Present 3-10 Similar as in the control.
Specimen 3 Rb1cc1-cKO Middle: postnatal day 1; Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: anterior commissure Present 3-11 Similar as in the control.
TS27: corpus callosum Present 3-11 Similar as in the control.
TS27: hippocampal commissure Present 3-11 Similar as in the control.
Specimen 3 Rb1cc1-cKO Caudal: postnatal day 1; Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebral internal capsule Present 3-12 Similar as in the control.
TS27: external capsule Present 3-12 Similar as in the control.
Specimen 8A control: embryonic day 18.5 (more )
Note: Double labeled: green - Chl1; red - Ncam1 (assay MGI:7616445).
Structure Level Pattern Image Note
TS26: cerebral cortex Present 8A1
Specimen 8A DKO: embryonic day 18.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Note: Double labeled: green - Chl1; red - Ncam1 (assay MGI:7616445).
Structure Level Pattern Image Note
TS26: cerebral cortex Present 8A2
Specimen 8B control: embryonic day 18.5 (more )
Note: Double labeled: green - Chl1; red - Cntn2 (assay MGI:7616446).
Structure Level Pattern Image Note
TS26: cerebral cortex Present 8B1
TS26: forebrain Present 8B1
Specimen 8B DKO: embryonic day 18.5; Ulk1tm1.1Thsn/Ulk1tm1.1Thsn, Ulk2tm1.1Thsn/Ulk2tm1.1Thsn (more )
Note: Double labeled: green - Chl1; red - Cntn2 (assay MGI:7616446).
Structure Level Pattern Image Note
TS26: cerebral cortex Present 8B2
TS26: forebrain Present 8B2
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory