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Gene Expression Data
Assay Details
Assay
Reference: J:334252 Zapata G, et al., Generation of a mouse model of the neurodevelopmental disorder with dysmorphic facies and distal limb anomalies syndrome. Hum Mol Genet. 2022 Oct 10;31(20):3405-3421
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7595955
Gene symbol: Tbr1
Gene name: T-box brain transcription factor 1
Results
Specimen 4A Ctrl: postnatal day 2 (more )
Note: Triple labeled: red - Tbr1; gray - Bcl11b (assay MGI:7595954); green - Satb2 (assay MGI:7595953).
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted 4A Ctrl Tbr1 , 4A Ctrl (merged) Expression in cortical layer VI.
Specimen 4A cKO: postnatal day 2; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: red - Tbr1; gray - Bcl11b (assay MGI:7595954); green - Satb2 (assay MGI:7595953).
Structure Level Pattern Image Note
TS27: neocortex Weak Regionally restricted 4A cKO Tbr1 , 4A cKO (merged) Proportion of early born neurons significantly reduced.
Specimen 4B Ctrl: postnatal day 2 (more )
Note: Triple labeled: red - Tbr1; gray - Bcl11b (assay MGI:7595954); green - Satb2 (assay MGI:7595953).
Structure Level Pattern Image Note
TS27: cortical layer VI Present 4B Ctrl Tbr1 , 4B Ctrl Merge
Specimen 4B cKO: postnatal day 2; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: red - Tbr1; gray - Bcl11b (assay MGI:7595954); green - Satb2 (assay MGI:7595953).
Structure Level Pattern Image Note
TS27: cortical layer VI Weak 4B cKO Merge , 4B cKO Tbr1 Proportion of early born neurons significantly reduced compared to control or heterozygote.
Specimen 4C: postnatal day 2; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: red - Tbr1; gray - Bcl11b (assay MGI:7595954); green - Satb2 (assay MGI:7595953).
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted 4C Satb2-Ctip2-Tbr1 , 4C Ctip2-Tbr1
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory