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Gene Expression Data
Assay Details
Assay
Reference: J:181601 Bassett EA, et al., Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina. Dev Dyn. 2012 Apr;241(4):814-29
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7579012
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2
Detection system: Secondary antibody coupled to Alexa Fluor 568
Results
Specimen 4K: postnatal day 0 (more )
Note: Double labeled: red - Sox2; green - Tfap2c (assay MGI:7579003).
Structure Cell Type Level Pattern Image Note
TS27: neural retina amacrine cell Present Regionally restricted 4K Expression was detected in cholinergic amacrine cells. There was no overlap with Tfap2c immunoreactivity.
Specimen 4L: postnatal day 0 (more )
Note: Double labeled: red - Sox2; green - Tfap2a (assay MGI:7578959).
Structure Cell Type Level Pattern Image Note
TS27: neural retina amacrine cell Present Regionally restricted 4L Expression was detected in cholinergic amacrine cells. Expressed co-localized with Tfap2a.
Specimen 4M: postnatal day 0 (more )
Note: Double labeled: red - Sox2; green - Tfap2b (assay MGI:7578963).
Structure Cell Type Level Pattern Image Note
TS27: neural retina amacrine cell Present Regionally restricted 4M Expression was detected in cholinergic amacrine cells. Expressed co-localized with Tfap2b.
Specimen 8G: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: retina ganglion cell layer amacrine cell Present Regionally restricted 8G Expression was detected in cholinergic amacrine cells.
TS26: retina inner nuclear layer amacrine cell Present Regionally restricted 8G Expression was detected in cholinergic amacrine cells.
Specimen 8H: embryonic day 18.5; Tfap2atm1Hsv/Tfap2atm1.1Hsv, Tfap2btm1Rbu/Tfap2btm1Rbu, Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: retina ganglion cell layer amacrine cell Present Regionally restricted 8H Expression was detected in cholinergic amacrine cells in the mutant, but the orderly distribution of the labeled cells was disrupted.
TS26: retina inner nuclear layer amacrine cell Present Regionally restricted 8H Expression was detected in cholinergic amacrine cells in the mutant, but the orderly distribution of the labeled cells was disrupted.
Specimen not shown P0: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: retina Mueller cell Present Sox2-positive Muller glial cells were not co-labeled with Tfap2c.
Specimen not shown P7: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina Mueller cell Present Sox2-positive Muller glial cells were not co-labeled with Tfap2c.
Specimen not shown P21: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina Mueller cell Present Sox2-positive Muller glial cells were not co-labeled with Tfap2c.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory