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Gene Expression Data
Assay Details
Assay
Reference: J:93057 Schuurmans C, et al., Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J. 2004 Jul 21;23(14):2892-902
Assay type: RNA in situ
MGI Accession ID: MGI:7578965
Gene symbol: Gad1
Gene name: glutamate decarboxylase 1
Probe: GAD67 cDNA
Probe preparation: Antisense RNA
Results
Specimen 1N: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cerebral cortex Present Regionally restricted 1N Expressed in the subcortical region.
Specimen 1O: embryonic day 13.5; Neurog2tm2Fgu/Neurog2tm2Fgu (more )
Structure Level Pattern Image Note
TS21: cerebral cortex subventricular zone Present 1O Ectopically expressed compared with the wild-type.
TS21: cortical plate Present 1O Ectopically expressed compared with the wild-type.
TS21: cortical preplate Present 1O Ectopically expressed compared with the wild-type.
Specimen 1P: embryonic day 13.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm2Fgu/Neurog2tm2Fgu (more )
Structure Level Pattern Image Note
TS21: cerebral cortex subventricular zone Present 1P Ectopically expressed compared with the wild-type.
TS21: cortical plate Present 1P Ectopically expressed compared with the wild-type.
TS21: cortical preplate Present 1P Ectopically expressed compared with the wild-type.
Specimen 1Q: embryonic day 13.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS21: cortical preplate Weak 1Q
Specimen 1R/S: embryonic day 13.5 (more )
Note: Double labeled: blue - Gad1; brown - Slc17a7 (assay MGI:7578966).
Structure Level Pattern Image Note
TS21: cerebral cortex Present 1S , 1R For the most part, no co-expression with Slc17a7/VGLUT1.
Specimen 1T/U: embryonic day 13.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm2Fgu/Neurog2tm2Fgu (more )
Note: Double labeled: blue - Gad1; brown - Slc17a7 (assay MGI:7578966).
Structure Level Pattern Image Note
TS21: cerebral cortex subventricular zone Present 1U , 1T For the most part, no co-expression with Slc17a7/VGLUT1.
TS21: cortical plate Present 1U , 1T For the most part, no co-expression with Slc17a7/VGLUT1.
TS21: cortical preplate Present 1U , 1T For the most part, no co-expression with Slc17a7/VGLUT1.
Specimen not shown Ngn2-/-: embryonic day 15.5; Neurog2tm2Fgu/Neurog2tm2Fgu (more )
Structure Level Pattern Image Note
TS23: cortical plate Present Clusters Ectopic expression as large aggregates in lower region was seen, and was excluded from the more recently generated, superficial layer.
Specimen not shown Ngn1-/-;Ngn2-/-: embryonic day 15.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm2Fgu/Neurog2tm2Fgu (more )
Structure Level Pattern Image Note
TS23: cortical plate Present Clusters Ectopic expression as large aggregates in lower region was seen, and was excluded from the more recently generated, superficial layer.
Specimen not shown Ngn2-/-: embryonic day 18.5; Neurog2tm2Fgu/Neurog2tm2Fgu (more )
Structure Level Pattern Image Note
TS26: cerebral cortex Present Clusters Ectopically expressed in small clusters in the germinal zone, rostral marginal zone and flanking the intermediate zone/lower cortical plate border.
Specimen not shown Ngn1-/-;Ngn2-/-: embryonic day 18.5; Neurog1tm1And/Neurog1tm1And, Neurog2tm2Fgu/Neurog2tm2Fgu (more )
Structure Level Pattern Image Note
TS26: cerebral cortex Present Clusters Ectopically expressed in small clusters in the germinal zone, rostral marginal zone and flanking the intermediate zone/lower cortical plate border.
Specimen not shown Pax6-/-: embryonic day 15.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS23: cerebral cortex Present Ectopic upregulation of expression was seen, compared with the wild-type.
Specimen not shown Pax6-/-;Tlx-/-: embryonic day 15.5; Nr2e1tm1Rtyu/Nr2e1tm1Rtyu, Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS23: cerebral cortex Present Ectopic upregulation of expression was seen, compared with the wild-type.
Specimen not shown Tlx-/-: embryonic day 18.5; Nr2e1tm1Rtyu/Nr2e1tm1Rtyu (more )
Structure Level Pattern Image Note
TS26: cerebral cortex Present Clusters Expressed in small ectopic clusters in the germinal zone.
Specimen not shown Pax6-/-: embryonic day 18.5; Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS26: cerebral cortex Present Regionally restricted Expressed in a grossly expanded germinal zone, compared with the wild-type.
Specimen not shown Pax6-/-;Tlx-/-: embryonic day 18.5; Nr2e1tm1Rtyu/Nr2e1tm1Rtyu, Pax6Sey/Pax6Sey (more )
Structure Level Pattern Image Note
TS26: cerebral cortex Present Regionally restricted Expressed in a grossly expanded germinal zone, compared with the wild-type.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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