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Gene Expression Data
Assay Details
Assay
Reference: J:129202 Dunty WC Jr, et al., Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation. Development. 2008 Jan;135(1):85-94
Assay type: RNA in situ
MGI Accession ID: MGI:7574675
Gene symbol: Uncx
Gene name: UNC homeobox
Probe: Uncx4.1 cDNA1
Probe preparation: Antisense RNA
Results
Specimen 3A: embryonic day 8.0 (more )
Note: 4-6 somites
Structure Level Pattern Image Note
TS12: somite Present 3A
Specimen 3B: embryonic day 8.0 (more )
Note: 4-6 somites
Structure Level Pattern Image Note
TS12: somite Present 3B
Specimen 3C: embryonic day 8.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant. 4-6 somites
Structure Level Pattern Image Note
TS13: somite Present Regionally restricted 3C Still expressed in a segmented pattern in the mutant somites. Stripes were notably absent from the anterior-most paraxial mesoderm, and were compressed and posteriorly shifted, demonstrating that segmentation proceeded but was delayed.
Specimen 3D: embryonic day 8.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant. 4-6 somites
Structure Level Pattern Image Note
TS13: somite Present Regionally restricted 3D Still expressed in a segmented pattern in the mutant somites. Stripes were notably absent from the anterior-most paraxial mesoderm, and were compressed and posteriorly shifted, demonstrating that segmentation proceeded but was delayed.
Specimen 3E: embryonic day 8.0; Ctnnb1tm1Mmt/Ctnnb1+, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant. 4-6 somites
Structure Level Pattern Image Note
TS12: somite Present Regionally restricted 3E An anterior shift was seen. Expressed as two distinct stripes anteriorly, but was fused and disorganized posteriorly.
Specimen 3F: embryonic day 8.0; Ctnnb1tm1Mmt/Ctnnb1+, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant. 4-6 somites
Structure Level Pattern Image Note
TS12: somite Present Regionally restricted 3F Expressed as two distinct stripes anteriorly, but was fused and disorganized posteriorly.
Specimen not shown: embryonic day 9.0-9.5; Ctnnb1tm2Kem/Ctnnb1tm2Kem, Tg(T-cre)1Lwd/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS14: paraxial mesenchyme Absent Stripes were no longer detectable in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory