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Gene Expression Data
Assay Details
Assay
Reference: J:67383 Britsch S, et al., The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev. 2001 Jan 1;15(1):66-78
Assay type: RNA in situ
MGI Accession ID: MGI:7569214
Gene symbol: Sox10
Gene name: SRY (sex determining region Y)-box 10
Probe: Sox10 probe
Probe preparation: Antisense RNA
Results
Specimen 2a: embryonic day 10.5 (more )
Structure Cell Type Level Pattern Image Note
TS17: migrating neural crest migratory neural crest cell Strong 2a Positive cells were abundant in cranial ganglia and their projections and along the axon tracts.
TS17: myotome Absent 2a
TS17: sympathetic nervous system Present Regionally restricted 2a Expressed in the anlage of the primary sympathetic ganglion chain.
TS17: cranial ganglion Present 2a Expressed in cranial ganglia and their projections.
TS17: dorsal root ganglion Present 2a

Specimen 2c: embryonic day 10.5 (more )
Structure Cell Type Level Pattern Image Note
TS17: sympathetic nervous system Present Regionally restricted 2c Expressed in the anlage of the primary sympathetic ganglion chain.
TS17: migrating neural crest migratory neural crest cell Present 2c
TS17: myotome Absent 2c
TS17: dorsal root ganglion Present 2c

Specimen 2e: embryonic day 10.5; Sox10Dom/Sox10Dom (more )
Structure Cell Type Level Pattern Image Note
TS17: migrating neural crest migratory neural crest cell Present 2e Significantly reduced in numbers compared with the wild-type. Less severe compared with the Erbb3 mutants.
TS17: cranial ganglion Trace 2e Only remnants were present.
TS17: dorsal root ganglion Present 2e Similar size as those of control embryos.

Specimen 2g: embryonic day 10.5; Sox10Dom/Sox10Dom (more )
Structure Cell Type Level Pattern Image Note
TS17: migrating neural crest migratory neural crest cell Present 2g Significantly reduced in numbers compared with the wild-type.
TS17: myotome Absent 2g
TS17: sympathetic nervous system Weak Regionally restricted 2g Expressed in the anlage of the primary sympathetic ganglion chain, which was severely hypoplastic with a rostro-caudal gradient in the mutant.
TS17: dorsal root ganglion Present 2g Similar size as those of control embryos.

Specimen 2i: embryonic day 9.0; Sox10Dom/Sox10Dom (more )
Structure Cell Type Level Pattern Image Note
TS14: migrating neural crest migratory neural crest cell Present Widespread 2i

Specimen 2k: embryonic day 9.0; Sox10Dom/Sox10Dom (more )
Structure Cell Type Level Pattern Image Note
TS14: migrating neural crest migratory neural crest cell Present Widespread 2k

Specimen 2m: embryonic day 10.5; Erbb3tm2Cbm/Erbb3tm2Cbm (more )
Structure Cell Type Level Pattern Image Note
TS17: migrating neural crest migratory neural crest cell Present 2m Significantly reduced in numbers compared with the wild-type.
TS17: cranial ganglion Trace 2m Only remnants were present.
TS17: dorsal root ganglion Present 2m Similar size as those of control embryos.

Specimen 2o: embryonic day 10.5; Erbb3tm2Cbm/Erbb3tm2Cbm (more )
Structure Cell Type Level Pattern Image Note
TS17: migrating neural crest migratory neural crest cell Present 2o Significantly reduced in numbers compared with the wild-type.
TS17: sympathetic nervous system Weak Regionally restricted 2o Expressed in the anlage of the primary sympathetic ganglion chain, which was severely hypoplastic with a rostro-caudal gradient in the mutant.
TS17: dorsal root ganglion Present 2o Similar size as those of control embryos.

Specimen 4g: embryonic day 11.5 (more )
Structure Cell Type Level Pattern Image Note
TS19: dorsal root ganglion glial cell Strong 4g
TS19: dorsal root ganglion migratory neural crest cell Strong 4g
TS19: spinal nerve glial cell Strong 4g
TS19: spinal nerve migratory neural crest cell Strong 4g
TS19: migrating neural crest melanocyte Present Regionally restricted 4g Expressed in migrating cells after they had moved a short distance from the neural tube.

Specimen 4i: embryonic day 11.5; Sox10Dom/Sox10Dom (more )
Structure Cell Type Level Pattern Image Note
TS19: dorsal root ganglion migratory neural crest cell Present 4i Reduced numbers of positive cells, compared with the wild-type.
TS19: spinal nerve migratory neural crest cell Present 4i Reduced numbers of positive cells, compared with the wild-type.
TS19: migrating neural crest melanocyte Present 4i Reduced numbers of positive cells, compared with the wild-type.

Specimen 4k: embryonic day 11.5; Erbb3tm2Cbm/Erbb3tm2Cbm (more )
Structure Cell Type Level Pattern Image Note
TS19: dorsal root ganglion Strong 4k
TS19: spinal nerve Weak 4k Severely reduced along the spinal nerve.
TS19: migrating neural crest melanocyte Present 4k Similar as in the wild-type.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory