Gene Expression Data
Assay Details
Assay
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Reference:
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J:67383
Britsch S, et al., The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev. 2001 Jan 1;15(1):66-78
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Assay type:
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RNA in situ
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MGI Accession ID:
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MGI:7569214
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Gene symbol:
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Sox10
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Gene name:
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SRY (sex determining region Y)-box 10
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Results
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Specimen
2a:
embryonic day 10.5
(more )
Specimen
2a:
(close )
Genetic Background:
|
Not Specified
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Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
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Fixation:
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4% Paraformaldehyde
|
Specimen
2c:
embryonic day 10.5
(more )
Specimen
2c:
(close )
Genetic Background:
|
Not Specified
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Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section from whole mount
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Fixation:
|
4% Paraformaldehyde
|
Embedding:
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Gelatin
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Specimen
2e:
(close )
Genetic Background:
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involves: C3HeB/FeJLe * C57BL/6JLe
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Mutant Allele(s):
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Sox10Dom/Sox10Dom
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Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
2g:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6JLe
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Mutant Allele(s):
|
Sox10Dom/Sox10Dom
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Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section from whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Gelatin
|
Specimen
2i:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6JLe
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Mutant Allele(s):
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Sox10Dom/Sox10Dom
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Age:
|
embryonic day 9.0
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
2k:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6JLe
|
Mutant Allele(s):
|
Sox10Dom/Sox10Dom
|
Age:
|
embryonic day 9.0
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
2m:
(close )
Genetic Background:
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involves: 129P2/OlaHsd
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Mutant Allele(s):
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Erbb3tm2Cbm/Erbb3tm2Cbm
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Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
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Type:
|
whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
2o:
(close )
Genetic Background:
|
involves: 129P2/OlaHsd
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Mutant Allele(s):
|
Erbb3tm2Cbm/Erbb3tm2Cbm
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Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
section from whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
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Gelatin
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Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS17: migrating neural crest |
migratory neural crest cell |
Present |
|
2o
|
Significantly reduced in numbers compared with the wild-type.
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TS17: sympathetic nervous system |
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Weak |
Regionally restricted |
2o
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Expressed in the anlage of the primary sympathetic ganglion chain, which was severely hypoplastic with a rostro-caudal gradient in the mutant.
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TS17: dorsal root ganglion |
|
Present |
|
2o
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Similar size as those of control embryos.
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Specimen
4g:
embryonic day 11.5
(more )
Specimen
4g:
(close )
Genetic Background:
|
Not Specified
|
Age:
|
embryonic day 11.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
4i:
(close )
Genetic Background:
|
involves: C3HeB/FeJLe * C57BL/6JLe
|
Mutant Allele(s):
|
Sox10Dom/Sox10Dom
|
Age:
|
embryonic day 11.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
TS19: dorsal root ganglion |
migratory neural crest cell |
Present |
|
4i
|
Reduced numbers of positive cells, compared with the wild-type.
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TS19: spinal nerve |
migratory neural crest cell |
Present |
|
4i
|
Reduced numbers of positive cells, compared with the wild-type.
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TS19: migrating neural crest |
melanocyte |
Present |
|
4i
|
Reduced numbers of positive cells, compared with the wild-type.
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Specimen
4k:
(close )
Genetic Background:
|
involves: 129P2/OlaHsd
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Mutant Allele(s):
|
Erbb3tm2Cbm/Erbb3tm2Cbm
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Age:
|
embryonic day 11.5
|
Sex:
|
Not Specified
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Type:
|
section
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Fixation:
|
4% Paraformaldehyde
|
|