Fbn1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:321553 Neupane S, et al., O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development. Matrix Biol. 2022 Feb 12;
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7567574
Gene symbol:	Fbn1
Gene name:	fibrillin 1

Antibody:	anti-FBN1 (pAb9543)
Assay notes:	Fixation was with 5% acetic acid in ethanol.

Results

Specimen 3E,F: embryonic day 14.5; Pofut2^tm2.1Bch/Pofut2⁺, Tg(Prrx1-cre)1Cjt/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS22: hindlimb	Present	Widespread	3E	Expression throughout limb.
TS22: tibia cartilage condensation	Present	Regionally restricted	3E , 3F' , 3F	Expression in hypertrophic and perichondrium regions.

Specimen 3G,H: embryonic day 14.5; Pofut2^tm2.1Bch/Pofut2^tm2.2Bch, Tg(Prrx1-cre)1Cjt/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS22: tibia cartilage condensation	Weak	Regionally restricted	3G , 3H' , 3H	Expression in hypertrophic and perichondrium regions decreased compared to control.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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