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Gene Expression Data
Assay Details
Assay
Reference: J:329220 Chen Y, et al., Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1alpha-glycolysis axis. Cell Death Dis. 2022 Sep 20;13(9):803
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7546916
Gene symbol: Hnrnpk
Gene name: heterogeneous nuclear ribonucleoprotein K
Antibody: anti-Hnrnpk [EP943Y] (ab52600)
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen S1A Hnrnpk: embryonic day 13.5; Hnrnpktm1.1Cya/Hnrnpktm1.1Cya (more )
Structure Level Pattern Image Note
TS21: humerus cartilage condensation Present S1A Hnrnpk Expression in cartilage primordia coincident with expression of Sox9.
TS21: upper arm mesenchyme Present Scattered S1A Hnrnpk Scattered expression in adjacent soft tissue.

Specimen S1B Hnrnpk: embryonic day 15.5; Hnrnpktm1.1Cya/Hnrnpktm1.1Cya (more )
Structure Level Pattern Image Note
TS23: humerus Present Widespread S1B Hnrnpk Widely expressed in long bone and ossification center.
TS23: upper arm mesenchyme Present Widespread S1B Hnrnpk Widely expressed in adjacent soft tissue.

Specimen S1C Hnrnpk: embryonic day 18.5; Hnrnpktm1.1Cya/Hnrnpktm1.1Cya (more )
Structure Cell Type Level Pattern Image Note
TS26: humerus growth plate cartilage chondrocyte Present Regionally restricted S1C Hnrnpk Partially expressed in proliferating chondrocytes, different from entire expression in resting and hypertrophic zones.
TS26: upper arm mesenchyme Present Widespread S1C Hnrnpk Widely expressed in adjacent soft tissue.

Specimen S1C Resting zone: embryonic day 18.5; Hnrnpktm1.1Cya/Hnrnpktm1.1Cya (more )
Structure Level Pattern Image Note
TS26: long bone epiphyseal plate resting zone Present S1C Resting zone

Specimen S1C Proliferating zone: embryonic day 18.5; Hnrnpktm1.1Cya/Hnrnpktm1.1Cya (more )
Structure Cell Type Level Pattern Image Note
TS26: long bone epiphyseal plate proliferative zone growth plate cartilage chondrocyte Present Regionally restricted S1C Proliferating zone Partially expressed in proliferating chondrocytes, different from entire expression in resting and hypertrophic zones.

Specimen S1C Hypertrophic zone: embryonic day 18.5; Hnrnpktm1.1Cya/Hnrnpktm1.1Cya (more )
Structure Level Pattern Image Note
TS26: long bone epiphyseal plate hypertrophic zone Present S1C Hypertrophic zone

Specimen S1F WT: embryonic day 15.5; Hnrnpktm1.1Cya/Hnrnpktm1.1Cya (more )
Structure Level Pattern Image Note
TS23: long bone epiphyseal plate Present S1F WT

Specimen S1F CKO: embryonic day 15.5; Hnrnpktm1.1Cya/Hnrnpktm1.1Cya, Tg(Col2a1-cre)1Xya/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: long bone epiphyseal plate Absent S1F CKO


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory