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Gene Expression Data
Assay Details
Assay
Reference: J:338243 Christova T, et al., LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity. EMBO Rep. 2023 Jul 5;24(7):e56937
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7544891
Gene symbol: Eomes
Gene name: eomesodermin
Antibody: anti-Eomes/Tbr2 (ab23345)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 1A WT Sox2/Tbr2: embryonic day 15.5 (more )
Note: Double labeled: red - Eomes; green - Sox2 (assay MGI:7544888).
Structure Level Pattern Image Note
TS23: cerebral cortex subventricular zone Present Regionally restricted 1A WT Sox2/Tbr2 Expression was detected in the intermediate neuronal progenitor cells.
Specimen 1A DKO Sox2/Tbr2: embryonic day 15.5; Alktm1Swm/Alktm1Swm, Ltktm1Rabr/Ltktm1Rabr (more )
Note: Double labeled: red - Eomes; green - Sox2 (assay MGI:7544888).
Structure Level Pattern Image Note
TS23: cerebral cortex subventricular zone Present Regionally restricted 1A DKO Sox2/Tbr2 Expression was detected in the intermediate neuronal progenitor cells. A dramatic reduction of immunopositive cells was observed.
Specimen EV2A WT Sox2/Tbr2: embryonic day 15.5 (more )
Note: Double labeled: red - Eomes; green - Sox2 (assay MGI:7544888).
Structure Level Pattern Image Note
TS23: cerebral cortex subventricular zone Present Regionally restricted EV2A WT Sox2/Tbr2 Expression was detected in the intermediate neuronal progenitor cells.
Specimen EV2A Alk-/- Sox2/Tbr2: embryonic day 15.5; Alktm1Swm/Alktm1Swm (more )
Note: Double labeled: red - Eomes; green - Sox2 (assay MGI:7544888).
Structure Level Pattern Image Note
TS23: cerebral cortex subventricular zone Present Regionally restricted EV2A Alk-/- Sox2/Tbr2 Expression was detected in the intermediate neuronal progenitor cells. A reduction of immunopositive cells was observed.
Specimen EV2A Ltk-/- Sox2/Tbr2: embryonic day 15.5; Ltktm1Rabr/Ltktm1Rabr (more )
Note: Double labeled: red - Eomes; green - Sox2 (assay MGI:7544888).
Structure Level Pattern Image Note
TS23: cerebral cortex subventricular zone Present Regionally restricted EV2A Ltk-/- Sox2/Tbr2 Expression was detected in the intermediate neuronal progenitor cells. A reduction of immunopositive cells was observed.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory