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Gene Expression Data
Assay Details
Assay
Reference: J:341326 Nag P, et al., Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft Enamel in Mouse. J Dent Res. 2023 Sep;102(10):1162-1171
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7539815
Gene symbol: Cldn1
Gene name: claudin 1
Antibody: claudin-1 antibody (ab15098)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 4D Control: postnatal day 14; Cemip2tm1.1Cya/? (more )
Note: Tmem2flox/flox or Tmem2flox/+ offspring without Cre were used as controls. Double labeled: green - Cldn1; red - phalloidin.
Structure Cell Type Level Pattern Image Note
TS28: incisor enamel organ ameloblast Present Regionally restricted 4D Merged Control , 4D Claudin1 Control
Specimen 4D CKO: postnatal day 14; Cemip2tm1.1Cya/Cemip2tm1.1Cya, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant. Double labeled: green - Cldn1; red - phalloidin.
Structure Level Pattern Image Note
TS28: incisor enamel organ Weak Regionally restricted 4D Claudin1 CKO , 4D Merged CKO Substantially weaker expression at interface between stratum intermedium and basal end of secretory ameloblasts compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory