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Gene Expression Data
Assay Details
Assay
Reference: J:341326 Nag P, et al., Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft Enamel in Mouse. J Dent Res. 2023 Sep;102(10):1162-1171
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7539813
Gene symbol: Vcl
Gene name: vinculin
Antibody: anti-vinculin (V4505)
Detection system: Secondary antibody coupled to Alexa Fluor 546
Results
Specimen 4A Control: postnatal day 14; Cemip2tm1.1Cya/? (more )
Note: Tmem2flox/flox or Tmem2flox/+ offspring without Cre were used as controls.
Structure Cell Type Level Pattern Image Note
TS28: stratum intermedium Present 4A Vinculin Control (upper) , 4A Vinculin Control (lower) , 4A Merged Control
TS28: incisor enamel organ ameloblast Present Regionally restricted 4A Vinculin Control (upper) , 4A Merged Control , 4A Vinculin Control (lower) Expression in basal end and Tomes processes of secretory ameloblasts.
Specimen 4A CKO: postnatal day 14; Cemip2tm1.1Cya/Cemip2tm1.1Cya, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: incisor enamel organ Weak Regionally restricted 4A Vinculin CKO (lower) , 4A Merged CKO , 4A Vinculin CKO (upper) Expression markedly reduced at interface between stratum intermedium and basal end of secretory ameloblasts compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory