Trp63 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:321979 Kurz J, et al., Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter. Development. 2022 Feb 15;149(4):dev199735
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7539751
Gene symbol:	Trp63
Gene name:	transformation related protein 63

Antibody:	Anti-deltaNp63 (619001)
Detection system:	Secondary antibody coupled to Alexa Fluor 555

Results

Specimen S6A control: embryonic day 18.5; Rbpj^tm1Hon/? (more

)
Note: Controls were littermates with no cre.

Structure	Level	Pattern	Image	Note
TS26: urothelium of ureter	Present		S6A control delta NP63

Specimen S6A Rbpj-cKO: embryonic day 18.5; Rbpj^tm1Hon/Rbpj^tm1Hon, Tbx18^tm4(cre)Akis/Tbx18⁺ (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS26: urothelium of ureter	Present		S6A Rbpj-cKO delta NP63	Normal urothelial differentiation was seen in the mutant compared with control.

Specimen S6B control: postnatal day 4; Rbpj^tm1Hon/? (more

)
Note: Controls were littermates with no cre.

Structure	Cell Type	Level	Image
TS28: urothelium of ureter	basal cell of urothelium	Present	S6B control delta NP63 , S6B control Krt5 delta NP63
TS28: urothelium of ureter	intermediate cell of urothelium	Present	S6B control delta NP63 , S6B control Krt5 delta NP63
TS28: urothelium of ureter	umbrella cell of urothelium	Absent	S6B control delta NP63 , S6B control Krt5 delta NP63

Specimen S6B Rbpj-cKO: postnatal day 4; Rbpj^tm1Hon/Rbpj^tm1Hon, Tbx18^tm4(cre)Akis/Tbx18⁺ (more

)
Note: Conditional mutant.

Structure	Cell Type	Level	Image	Note
TS28: urothelium of ureter	basal cell of urothelium	Present	S6B Rbpj-cKO delta NP63 , S6B Rbpj-cKO Krt5 delta NP63	Normal urothelial differentiation was seen in the mutant compared with control.
TS28: urothelium of ureter	intermediate cell of urothelium	Present	S6B Rbpj-cKO delta NP63 , S6B Rbpj-cKO Krt5 delta NP63	Normal urothelial differentiation was seen in the mutant compared with control.
TS28: urothelium of ureter	umbrella cell of urothelium	Absent	S6B Rbpj-cKO Krt5 delta NP63 , S6B Rbpj-cKO delta NP63	Normal urothelial differentiation was seen in the mutant compared with control.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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