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Gene Expression Data
Assay Details
Assay
Reference: J:165111 Doherty HE, et al., A mouse strain where basal connective tissue growth factor gene expression can be switched from low to high. PLoS One. 2010;5(9):e12909
Assay type: RT-PCR
MGI Accession ID: MGI:7539399
Gene symbol: Ccn2
Gene name: cellular communication network factor 2
Probe: Ctgf-pF, Ctgf-pR
Assay notes: Quantitative RT-PCR. Relative expression was normalized to was normalized to a combined control of animals with the genotypes: +/+;Cre-, +/+;Cre+, and Lo/+;Cre-.
Results
Image: 2D ©

 Sample Information Bands Other Sample Information
Lane AgeStructure Size Not Specified Amount Genetic BackgroundMutant Allele(s)Sex Note
Heart Control P m 10 TS28: heart Present Not Specified involves: 129S6/SvEvTac * C57BL/6 * FVB/N Not Specified Control could be any of these genotypes: +/+;Cre-; +/+;Cre+, or Lo/+;Cre-.
Heart Hi/+ P m 10 TS28: heart Present (a) Not Specified involves: 129S6/SvEvTac * C57BL/6 * FVB/N Ccn2tm2Mae/Ccn2+, Tg(EIIa-cre)C5379Lmgd/?Not Specified Conditional mutant.
Kidney Control P m 10 TS28: metanephros Present Not Specified involves: 129S6/SvEvTac * C57BL/6 * FVB/N Not Specified Control could be any of these genotypes: +/+;Cre-; +/+;Cre+, or Lo/+;Cre-.
Kidney Hi/+ P m 10 TS28: metanephros Present (b) Not Specified involves: 129S6/SvEvTac * C57BL/6 * FVB/N Ccn2tm2Mae/Ccn2+, Tg(EIIa-cre)C5379Lmgd/?Not Specified Conditional mutant.
Lung Control P m 10 TS28: lung Present Not Specified involves: 129S6/SvEvTac * C57BL/6 * FVB/N Not Specified Control could be any of these genotypes: +/+;Cre-; +/+;Cre+, or Lo/+;Cre-.
Lung Hi/+ P m 10 TS28: lung Present (c) Not Specified involves: 129S6/SvEvTac * C57BL/6 * FVB/N Ccn2tm2Mae/Ccn2+, Tg(EIIa-cre)C5379Lmgd/?Not Specified Conditional mutant.
Notes:
(a) There was a significant increase in expression in each tissue of Hi/+ animals. Heart expression was two-fold above controls.
(b) There was a significant increase in expression in each tissue of Hi/+ animals. Kidney expression was three-fold above controls.
(c) There was a significant increase in expression in each tissue of Hi/+ animals. Lung expression was nearly five-fold above controls.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory