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Gene Expression Data
Assay Details
Assay
Reference: J:224892 Yan Y, et al., Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nat Commun. 2015;6:7006
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7520131
Gene symbol: Olig2
Gene name: oligodendrocyte transcription factor 2
Antibody: anti-Olig2
Detection system: Secondary antibody
Results
Specimen 2g +/y: embryonic day 9.5 (more )
Note: Double labeled: green - Olig2; red - Isl1 (assay MGI:7520130) and Isl2 (assay MGI:7520256).
Structure Level Pattern Image Note
TS15: future spinal cord Strong Regionally restricted 2g Expressed at high levels by motor neuron progenitors but was decreased in newly differentiating cells in the intermediate zone.
Specimen 2j -y or -/-: embryonic day 9.5; Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: green - Olig2; red - Isl1 (assay MGI:7520130) and Isl2 (assay MGI:7520256).
Structure Level Pattern Image Note
TS15: future spinal cord Strong Regionally restricted 2j Roughly 30% increase of Olig2+Isl1/2+ cells, although there was no difference in the total Olig2+ numbers.
Specimen 3j -y or -/-: embryonic day 9.5; Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: green - Olig2; red - Isl1 (assay MGI:7520130) and Isl2 (assay MGI:7520256).
Structure Level Pattern Image Note
TS15: future spinal cord Strong Regionally restricted 3j Expressed at high levels by motor neuron progenitors but was decreased in newly differentiating cells in the intermediate zone.
Specimen 3k: embryonic day 9.5; Gdpd5tm1.1Itl/Gdpd5+, Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: green - Olig2; red - Isl1 (assay MGI:7520130) and Isl2 (assay MGI:7520256).
Structure Level Pattern Image Note
TS15: future spinal cord Present 3k The increase in newly differentiating Olig2+Isl+ cells observed in Prdx4 null animals was substantially reduced.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
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