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Gene Expression Data
Assay Details
Assay
Reference: J:224892 Yan Y, et al., Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nat Commun. 2015;6:7006
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7520130
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Antibody: clone 51.4H9
Detection system: Secondary antibody
Assay notes: The specificity of the antibody used was not detailed; both family members have been annotated.
Results
Specimen 2g +/y: embryonic day 9.5 (more )
Note: Double labeled: red - Isl1 and Isl2; green - Olig2 (assay MGI:7520131).
Structure Cell Type Level Pattern Image Note
TS15: future spinal cord spinal cord motor neuron Present 2g Expressed in newly differentiating and and postmitotic motor neurons.
Specimen 2j -y or -/-: embryonic day 9.5; Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: red - Isl1 and Isl2; green - Olig2 (assay MGI:7520131).
Structure Cell Type Level Pattern Image Note
TS15: future spinal cord spinal cord motor neuron Present 2j Expressed in newly differentiating and and postmitotic motor neurons.
Specimen 3j -y or -/-: embryonic day 9.5; Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: red - Isl1 and Isl2; green - Olig2 (assay MGI:7520131).
Structure Cell Type Level Pattern Image Note
TS15: future spinal cord spinal cord motor neuron Present 3j Expressed in newly differentiating and and postmitotic motor neurons.
Specimen 3k: embryonic day 9.5; Gdpd5tm1.1Itl/Gdpd5+, Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: red - Isl1 and Isl2; green - Olig2 (assay MGI:7520131).
Structure Cell Type Level Pattern Image Note
TS15: future spinal cord spinal cord motor neuron Present 3k The increase in Isl1/2+ cells observed in Prdx4 null animals was substantially reduced.
Specimen S3a +/y: embryonic day 13.5 (more )
Note: Double labeled: red - Isl1 and Isl2; green - Lhx3 (assay MGI:7520151).
Structure Cell Type Level Pattern Image Note
TS21: spinal cord ventral horn spinal cord motor neuron Present S3a
Specimen S3d -y or -/-: embryonic day 13.5; Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: red - Isl1 and Isl2; green - Lhx3 (assay MGI:7520151).
Structure Cell Type Level Pattern Image Note
TS21: spinal cord ventral horn spinal cord motor neuron Present S3d Medial median motor column (MMCm, Isl1/2+Lhx3+) motor neuron numbers were similar as in the wild-type littermates.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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