About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:224892 Yan Y, et al., Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nat Commun. 2015;6:7006
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7520126
Gene symbol: Prdx4
Gene name: peroxiredoxin 4
Antibody: anti-Prx4
Detection system: Secondary antibody
Results
Specimen 1d/e: embryonic day 9.5 (more )
Note: Double labeled: red - Prdx4; green - Isl1 (assay MGI:7520127) and Isl2 (assay MGI:7520255).
Structure Cell Type Level Pattern Image Note
TS15: future spinal cord Present Regionally restricted 1e , 1d Expressed in cycling motor neuron progenitors within the motor neuron progenitor domain.
TS15: future spinal cord spinal cord motor neuron Present Regionally restricted 1e , 1d Expressed in newly differentiating and and postmitotic Isl1/2+ motor neurons.
Specimen 1f: embryonic day 9.5 (more )
Note: Double labeled: red - Prdx4; green - BrdU.
Structure Level Pattern Image Note
TS15: future spinal cord Present 1f Expressed in both proliferating and postmitotic motor neurons.
Specimen 1g/h: embryonic day 10.5 (more )
Note: Double labeled: red - Prdx4; green - Isl1 (assay MGI:7520127) and Isl2 (assay MGI:7520255).
Structure Level Pattern Image Note
TS17: future spinal cord Present Regionally restricted 1g , 1h Expressed in ventricular and intermediate zone cells, but was not expressed by fully differentiated Isl1/2+ motor neurons in the lateral marginal zone.
Specimen 2f +/y: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future spinal cord Present 2f
Specimen 2i -y or -/-: embryonic day 9.5; Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified
Structure Level Pattern Image Note
TS15: future spinal cord Absent 2i
Specimen S5a: embryonic day 9.5 (more )
Note: Double labeled: red - Prdx4; green - KDEL.
Structure Cell Type Level Pattern Image Note
TS15: future spinal cord spinal cord motor neuron Present S5a Expression was localized to the ER in motor neurons, as Prdx4 colocalized with the ER marker KDEL.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory