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Gene Expression Data
Assay Details
Assay
Reference: J:224892 Yan Y, et al., Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nat Commun. 2015;6:7006
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7520127
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Antibody: anti-Isl1/2
Detection system: Secondary antibody
Assay notes: The specificity of the antibody used was not detailed; both family members have been annotated in some of the samples.
Results
Specimen 1d/e: embryonic day 9.5 (more )
Note: Double labeled: green - Isl1 and Isl2; red - Prdx4 (assay MGI:7520126).
Structure Cell Type Level Pattern Image Note
TS15: future spinal cord spinal cord motor neuron Present 1d , 1e Expressed in newly differentiating and and postmitotic motor neurons.
Specimen 1g/h: embryonic day 10.5 (more )
Note: Double labeled: green - Isl1 and Isl2; red - Prdx4 (assay MGI:7520126).
Structure Cell Type Level Pattern Image Note
TS17: future spinal cord spinal cord motor neuron Present 1h , 1g Expressed in newly differentiating and and postmitotic motor neurons.
Specimen S3g +/y: embryonic day 13.5 (more )
Note: Double labeled: green - Isl1; red - Etv1 (assay MGI:7520154).
Structure Cell Type Level Pattern Image Note
TS21: spinal cord ventral horn spinal cord motor neuron Present S3g
Specimen S3i -y or -/-: embryonic day 13.5; Prdx4tm1.1Jufu/? (more )
Note: The sex of the specimen was not specified. Double labeled: green - Isl1; red - Etv1 (assay MGI:7520154).
Structure Cell Type Level Pattern Image Note
TS21: spinal cord ventral horn spinal cord motor neuron Present S3i An increase in early-born adductor longus, adductor magnus and gracilis posterior motor pools (Etv1/Er81+Isl1+) and a corresponding decrease in late-born vasti motor pools (Etv1/Er81+Isl1-).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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