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Gene Expression Data
Assay Details
Assay
Reference: J:228828 Hamazaki J, et al., Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis. PLoS Genet. 2015 Jul;11(7):e1005401
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7511438
Gene symbol: Psmd4
Gene name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Antibody: anti-Rpn10 (C)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 3C Rpn10 Control: postnatal week 2 (more )
Structure Level Pattern Image Note
TS28: liver Present 3C Rpn10 Control
Specimen 3C Rpn10 DKO: postnatal week 2; Adrm1tm1Smta/Adrm1tm1Smta, Psmd4tm2.1Smta/Psmd4tm2.1Smta, Speer6-ps1Tg(Alb-cre)21Mgn/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: liver Absent 3C Rpn10 DKO Loss of expression confirmed.
Specimen 7C Rpn10 4w Control: postnatal week 4 (more )
Structure Level Pattern Image Note
TS28: liver Present 7C Rpn10 Control 4w
Specimen 7C Rpn10 4w DKO: postnatal week 4; Adrm1tm1Smta/Adrm1tm1Smta, Psmd4tm2.1Smta/Psmd4tm2.1Smta, Speer6-ps1Tg(Alb-cre)21Mgn/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: liver hepatocyte Weak Regionally restricted 7C Rpn10 DKO 4w Majority of hepatocytes expressed neither Rpn10 nor Rpn13, but some expressing areas appeared.
Specimen 7C Rpn10 4M Control: postnatal month 4 (more )
Structure Level Pattern Image Note
TS28: liver Present 7C Rpn10 Control 4M
Specimen 7C Rpn10 4M DKO: postnatal month 4; Adrm1tm1Smta/Adrm1tm1Smta, Psmd4tm2.1Smta/Psmd4tm2.1Smta, Speer6-ps1Tg(Alb-cre)21Mgn/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: liver hepatocyte Present Regionally restricted 7C Rpn10 DKO 4M Authors state majority of hepatocytes expressed either Rpn10 or Rpn13.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory