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Gene Expression Data
Assay Details
Assay
Reference: J:228828 Hamazaki J, et al., Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis. PLoS Genet. 2015 Jul;11(7):e1005401
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7511436
Gene symbol: Adrm1
Gene name: adhesion regulating molecule 1 26S proteasome ubiquitin receptor
Antibody: anti-Rpn13
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 1D Control: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: embryo Present 1D Control
Specimen 1D Rpn13KO: embryonic day 18.5; Adrm1tm1.1Smta/Adrm1tm1.1Smta (more )
Structure Level Pattern Image Note
TS26: embryo Absent 1D Rpn13KO Loss of expression confirmed.
Specimen 3C Rpn13 Control: postnatal week 2 (more )
Structure Level Pattern Image Note
TS28: liver Present 3C Rpn13 Control
Specimen 3C Rpn13 DKO: postnatal week 2; Adrm1tm1Smta/Adrm1tm1Smta, Psmd4tm2.1Smta/Psmd4tm2.1Smta, Speer6-ps1Tg(Alb-cre)21Mgn/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: liver Absent 3C Rpn13 DKO Loss of expression confirmed.
Specimen 7C Rpn13 4w Control: postnatal week 4 (more )
Structure Level Pattern Image Note
TS28: liver Present 7C Rpn13 Control 4w
Specimen 7C Rpn13 4w DKO: postnatal week 4; Adrm1tm1Smta/Adrm1tm1Smta, Psmd4tm2.1Smta/Psmd4tm2.1Smta, Speer6-ps1Tg(Alb-cre)21Mgn/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: liver hepatocyte Weak Regionally restricted 7C Rpn13 DKO 4w Majority of hepatocytes expressed neither Rpn10 nor Rpn13, but some expressing areas appeared.
Specimen 7C Rpn13 4M Control: postnatal month 4 (more )
Structure Level Pattern Image Note
TS28: liver Present 7C Rpn13 Control 4M
Specimen 7C Rpn13 4M DKO: postnatal month 4; Adrm1tm1Smta/Adrm1tm1Smta, Psmd4tm2.1Smta/Psmd4tm2.1Smta, Speer6-ps1Tg(Alb-cre)21Mgn/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: liver hepatocyte Present Regionally restricted 7C Rpn13 DKO 4M Authors state majority of hepatocytes expressed either Rpn10 or Rpn13.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory