Smoc1 In situ reporter (knock in) Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:174198 Rainger J, et al., Loss of the BMP Antagonist, SMOC-1, Causes Ophthalmo-Acromelic (Waardenburg Anophthalmia) Syndrome in Humans and Mice. PLoS Genet. 2011 Jul;7(7):e1002114
Assay type:	In situ reporter (knock in)
MGI Accession ID:	MGI:7506300
Gene symbol:	Smoc1
Gene name:	SPARC related modular calcium binding 1

Reporter:	lacZ
	Direct Detection
Assay notes:	Spatial and temporal expression data were similar between heterozygous and homozygous mutants, but with less intense staining in the heterozygous mice (data not shown).

Results

3c ©

Specimen 3c: embryonic day 10.5; Smoc1^{tm1a(EUCOMM)Wtsi}/Smoc1^{tm1a(EUCOMM)Wtsi} (more

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Structure	Level	Pattern	Image	Note
TS17: hindlimb bud	Present	Regionally restricted	3c	Expressed in the dorsal region.
TS17: forelimb bud	Present	Regionally restricted	3c	Expressed in the medial regions of dorsal and ventral forelimbs.
TS17: branchial arch	Present		3c
TS17: fronto-nasal process	Present		3c
TS17: somite	Present		3c
TS17: eye	Strong		3c

3d ©

Specimen 3d: embryonic day 10.5; Smoc1^{tm1a(EUCOMM)Wtsi}/Smoc1^{tm1a(EUCOMM)Wtsi} (more

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Structure	Level	Pattern	Image	Note
TS17: optic stalk	Strong	Regionally restricted	3d	Expressed in the ventral region.

3g ©

Specimen 3g: embryonic day 10.5; Smoc1^{tm1a(EUCOMM)Wtsi}/Smoc1^{tm1a(EUCOMM)Wtsi} (more

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Structure	Level	Pattern	Image	Note
TS17: 1st branchial arch mandibular component mesenchyme derived from head mesoderm	Present		3g	Expressed in proximal regions and absent from distal areas.
TS17: 1st branchial arch mandibular component mesenchyme derived from neural crest	Present		3g	Expressed in proximal regions and absent from distal areas.
TS17: 1st branchial arch maxillary component mesenchyme derived from head mesoderm	Present		3g	Expressed in proximal regions and absent from distal areas.
TS17: 1st branchial arch maxillary component mesenchyme derived from neural crest	Present		3g	Expressed in proximal regions and absent from distal areas.
TS17: 1st branchial arch mesenchyme	Present	Regionally restricted	3g	Most intense in the sub-epithelial mesenchyme within the hinge region. Sharp boundaries of expression are evident in the subepithelial mesenchyme.
TS17: 1st branchial arch maxillary-mandibular groove ectoderm	Present		3g	Expressed in the epithelial cells at the hinge region.

S2i ©

Specimen S2i: embryonic day 14.5; Smoc1^{tm1a(EUCOMM)Wtsi}/Smoc1^{tm1a(EUCOMM)Wtsi} (more

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Structure	Level	Pattern	Image	Note
TS22: bladder	Absent		S2i
TS22: metanephros	Absent		S2i

S2j ©

Specimen S2j: embryonic day 14.5; Smoc1^{tm1a(EUCOMM)Wtsi}/Smoc1^{tm1a(EUCOMM)Wtsi} (more

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Structure	Level	Pattern	Image	Note
TS22: intervertebral disc	Strong		S2j

S2k ©

Specimen S2k: embryonic day 14.5; Smoc1^{tm1a(EUCOMM)Wtsi}/Smoc1^{tm1a(EUCOMM)Wtsi} (more

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Structure	Level	Pattern	Image	Note
TS22: metanephros	Absent		S2k
TS22: adrenal gland	Present	Clusters	S2k

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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