Tg(Lck-EZH2*Y641F)1Rkh
Transgene Detail
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| Symbol: |
Tg(Lck-EZH2*Y641F)1Rkh |
| Name: |
transgene insertion 1, R Keith Humphries |
| MGI ID: |
MGI:7491716 |
| Transgene: |
Tg(Lck-EZH2*Y641F)1Rkh Location: unknown
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| Alliance: |
Tg(Lck-EZH2*Y641F)1Rkh page
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| Transgene Type: |
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Transgenic (Epitope tag, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Lck-EZH2*Y641F)1Rkh expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
EZH2 (2146) |
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Expresses a Y641F mutant form |
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Tg(Lck-EZH2*Y641F)1Rkh expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Lck (MGI:96756) |
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Mutation details: A mouse IgH enhancer upstream of a mouse Lck promoter drives expression of an HA-tagged human EZH2 gene with a mutation that alters codon 641 from tyrosine to phenylalanine.
(J:211280)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:211280 Berg T, et al., A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis. Blood. 2014 Jun 19;123(25):3914-24 |
| All: |
2 reference(s) |
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Analysis Tools
