Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itgb3bptm1.1Tfw
Name:	integrin beta 3 binding protein (beta3-endonexin); targeted mutation 1.1, Tatsuo Fukagawa
MGI ID:	MGI:7486275
Synonyms:	Cenp-r-, Itgb3bptm1.1Yuwa
Gene:	Itgb3bp  Location: Chr4:99655643-99717403 bp, - strand  Genetic Position: Chr4, 45.71 cM, cytoband C6
Alliance:	Itgb3bptm1.1Tfw page

Germline Transmission:	Earliest citation of germline transmission: J:271187
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The selection maker Beta-geo flanked by loxP sites was inserted in the 5 end of exon 4 and a third loxP site was inserted in the 3 end of exon 4. Exon 4 and the beta-geo selection marker were removed via cre-mediated recombination. Western blot analysis confirmed absence of protein. (J:271187)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb3bp Mutation:	16 strains or lines available

Original:	J:271187 Okumura K, et al., CENP-R acts bilaterally as a tumor suppressor and as an oncogene in the two-stage skin carcinogenesis model. Cancer Sci. 2017 Nov;108(11):2142-2148
All:	1 reference(s)