Phenotypes associated with this allele

• Allele Symbol: Itgb3bp^tm1.1Tfw
• Allele Name: targeted mutation 1.1, Tatsuo Fukagawa
• Allele ID: MGI:7486275
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgb3bp^tm1.1Tfw/Itgb3bp^tm1.1Tfw	involves: C57BL/6J	MGI:7488102

Genotype
MGI:7488102

hm1

• Allelic Composition: Itgb3bp^tm1.1Tfw/Itgb3bp^tm1.1Tfw
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor pathology ( J:271187 )

• chemically-treated mice have a lower incidence of carcinoma development as well as a later onset of carcinoma development; mice develop the first carcinoma at 23 weeks after initiation compared to 20 weeks for controls and less than 10% of mice develop carcinoma at 38 weeks compared to about 60% of wild-type mice

tumor regression ( J:271187 )

• within the 20 weeks after the initial DMBA treatment, some papillomas that form in mutant mice regress and regression is more notable after termination of the 20th week of TPA treatments

• mice develop fewer DMBA/TPA-induced papillomas than wild-type mice at 24 weeks after initiation, although not significantly

• mice develop fewer papillomas that are greater than 6 mm in diameter at 24 weeks of initiation compared to wild-type mice

• fewer Ki-67-positive cells are seen in DMBA/TPA-induced papillomas, indicating they grow more slowly

• more apoptotic cells are seen in DMBA/TPA-induced papillomas

abnormal incidence of induced tumors ( J:271187 )

• mice treated with a modified DMBA/TPA protocol develop more papillomas than controls between 8 and 20 weeks after the initial DMBA treatment

• however, within the 20 weeks after the initial DMBA treatment, some papillomas that form in mutant mice regress and regression is more notable after termination of the 20th week of TPA treatments

• chemically-treated mice have a lower incidence of carcinoma development as well as a later onset of carcinoma development

reproductive system

reproductive system phenotype ( J:271187 )

N • mice show normal fertility