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Gene Expression Data
Assay Details
Assay
Reference: J:207609 Hilliard SA, et al., Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol. 2014 Mar 1;387(1):1-14
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7481347
Gene symbol: Meis1
Gene name: Meis homeobox 1
Antibody: MEIS 1/2/3 antibody (Clone:9.2.7, 39795, 39796, 39096)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 9E: embryonic day 14.5 (more )
Note: Double labeled: green - Meis1; red - Six2 (assay MGI:7481327).
Structure Level Pattern Image Note
TS22: renal cortical interstitium Present 9E
Specimen 9F: embryonic day 14.5; Mdm2tm1.2Mep/Mdm2tm1.2Mep, Tg(Six2-GFP/cre)1Amc/0 (more )
Note: Conditional mutant. Double labeled: green - Meis1; red - Six2 (assay MGI:7481327).
Structure Level Pattern Image Note
TS22: renal cortical interstitium Present 9F The cortical stroma of the mutant kidney was several cell layers thick unlike the wild type littermate control kidneys.
Specimen 11G: postnatal day 0 (more )
Note: Double labeled: green - Meis1; red - Six2 (assay MGI:7481327).
Structure Level Pattern Image Note
TS27: renal cortical interstitium Present 11G
Specimen 11H: postnatal day 0; Mdm2tm1.2Mep/Mdm2tm1.2Mep, Tg(Six2-GFP/cre)1Amc/0 (more )
Note: Conditional mutant. Double labeled: green - Meis1; red - Six2 (assay MGI:7481327).
Structure Level Pattern Image Note
TS27: renal cortical interstitium Present 11H The cortical stroma of the mutant kidney was several cell layers thick unlike the wild type littermate control kidneys.
Specimen 11I: postnatal day 0; Mdm2tm1.2Mep/Mdm2tm1.2Mep, Tg(Six2-GFP/cre)1Amc/0, Trp53tm1Tyj/Trp53tm1Brn (more )
Note: Conditional mutant. Double labeled: green - Meis1; red - Six2 (assay MGI:7481327).
Structure Level Pattern Image Note
TS27: renal cortical interstitium Present 11I The proportion of cap mesenchyme to cortical stroma was restored.
Specimen not shown: embryonic day 13.5; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS21: nephrogenic interstitium Present
Specimen not shown: embryonic day 13.5; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Mdm2tm1.2Mep/Mdm2tm1.2Mep, Tg(Six2-GFP/cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: nephrogenic interstitium Present Six2+ cells did not undergo a fate change into stromal cells.
Specimen not shown: postnatal day 0; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Structure Level Pattern Image Note
TS27: renal cortical interstitium Present
Specimen not shown: postnatal day 0; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Mdm2tm1.2Mep/Mdm2tm1.2Mep, Tg(Six2-GFP/cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: renal cortical interstitium Present Six2+ cells did not undergo a fate change into stromal cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory