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Gene Expression Data
Assay Details
Assay
Reference: J:319765 Chen L, et al., Effect of Swell1 on regulating chondrocyte hypertrophy during the condylar osteochondral development process in mice. Biochem Biophys Res Commun. 2022 Jan 29;590:42-48
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7470963
Gene symbol: Lrrc8a
Gene name: leucine rich repeat containing 8A VRAC subunit A
Antibody: anti-Swell1
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 1 E14.5: embryonic day 14.5 (more )
Note: Double labeled: red - Lrrc8a; green - Sox9 (assay MGI:7470962).
Structure Level Pattern Image Note
TS22: mandible condylar condensation Absent 1_E14.5 merge , 1_E14.5 Swell1
Specimen 1 E16.5: embryonic day 16.5 (more )
Note: Double labeled: red - Lrrc8a; green - Sox9 (assay MGI:7470962).
Structure Level Pattern Image Note
TS24: mandible condylar process Present Regionally restricted 1_E16.5 Swell1 , 1_E16.5 merge Mainly began in the hypertrophic layer.
Specimen 1 E18.5: embryonic day 18.5 (more )
Note: Double labeled: red - Lrrc8a; green - Sox9 (assay MGI:7470962).
Structure Level Pattern Image Note
TS26: mandible condylar process Present 1_E18.5 merge , 1_E18.5 Swell1 Increased expression, being primarily located in the hypertrophic chondrocyte layer.
Specimen S2 E14.5: embryonic day 14.5 (more )
Note: Double labeled: red - Lrrc8a; green - Sox9 (assay MGI:7470962).
Structure Level Pattern Image Note
TS22: femur cartilage condensation Absent S2_E14.5 merge , S2_E14.5 Swell1
Specimen S2 E16.5: embryonic day 16.5 (more )
Note: Double labeled: red - Lrrc8a; green - Sox9 (assay MGI:7470962).
Structure Level Pattern Image Note
TS24: femur Present Regionally restricted S2_E16.5 merge , S2_E16.5 Swell1 Expressed in the femur condyle.
Specimen S2 E18.5: embryonic day 18.5 (more )
Note: Double labeled: red - Lrrc8a; green - Sox9 (assay MGI:7470962).
Structure Level Pattern Image Note
TS26: femur Present Regionally restricted S2_E18.5 merge , S2_E18.5 Swell1 Expressed in the femur condyle.
Specimen S3A WT: postnatal (more )
Note: Double labeled: red - Lrrc8a; green - Col10a1 (assay MGI:7471198).
Structure Cell Type Level Pattern Image Note
TS28: mandible condylar process hypertrophic chondrocyte Present S3A merge WT , S3A Swell1 WT
Specimen S3A cKO: postnatal; Col10a1em1(cre)Bcgen/Col10a1+, Lrrc8aem1Cya/Lrrc8aem1Cya (more )
Note: Conditional mutant. Double labeled: red - Lrrc8a; green - Col10a1 (assay MGI:7471198).
Structure Cell Type Level Pattern Image Note
TS28: mandible condylar process hypertrophic chondrocyte Present S3A merge cKO , S3A Swell1 cKO Less expression compared with the wild-type.
Specimen S3B WT: postnatal (more )
Note: Double labeled: red - Lrrc8a; green - Col10a1 (assay MGI:7471198).
Structure Cell Type Level Pattern Image Note
TS28: head of femur hypertrophic chondrocyte Present S3B merge WT , S3B Swell1 WT
Specimen S3B cKO: postnatal; Col10a1em1(cre)Bcgen/Col10a1+, Lrrc8aem1Cya/Lrrc8aem1Cya (more )
Note: Conditional mutant. Double labeled: red - Lrrc8a; green - Col10a1 (assay MGI:7471198).
Structure Cell Type Level Pattern Image Note
TS28: head of femur hypertrophic chondrocyte Present S3B merge cKO , S3B Swell1 cKO Less expression compared with the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory