Lrrc8a^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrc8a^em1Cya
• Name: leucine rich repeat containing 8A VRAC subunit A; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7442321
• Synonyms: Lrrc8a^em1Cflox, Lrrc8a^flox
• Gene: Lrrc8a Location: Chr2:30127781-30153802 bp, + strand Genetic Position: Chr2, 21.41 cM
• Alliance: Lrrc8a^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Exon 3 was flanked by loxP sites using CRISPR/Cas9 technology. (J:333466)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrc8a Mutation: 51 strains or lines available

References

• Original: J:333466 Chen X, et al., LRRC8A critically regulates myofibroblast phenotypes and fibrotic remodeling following myocardial infarction. Theranostics. 2022;12(13):5824-5835
• All: 2 reference(s)