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Gene Expression Data
Assay Details
Assay
Reference: J:333400 George RM, et al., Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis. Development. 2023 Feb 15;150(3):dev201341
Assay type: RNA in situ
MGI Accession ID: MGI:7461704
Gene symbol: Hand2
Gene name: heart and neural crest derivatives expressed 2
Probe: Hand2 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 2A: embryonic day 12.5; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Hand2tm1.1Majh/Hand2+ (more )
Structure Level Pattern Image Note
TS20: ventricle endocardial lining Present Regionally restricted 2A Expression was detected in the trabecular endocardium of the ventricles.
Specimen 2C: embryonic day 12.5; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+, Hand2tm1.1Majh/Hand2tm1.1Majh, Nfatc1tm1(cre)Bz/Nfatc1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: ventricle endocardial lining Weak Regionally restricted 2C Expression was significantly reduced in the trabecular endocardium of the ventricles in the H2CKO hearts compared with controls.
Specimen 5C: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: endocardial lining Present 5C
Specimen 5D: embryonic day 11.5; Rr417em1Abfi/Rr417em1Abfi (more )
Structure Level Pattern Image Note
TS19: endocardial lining Present 5D Expression was unchanged between controls and mutant hearts.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory