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Gene Expression Data
Assay Details
Assay
Reference: J:334253 Stavely R, et al., A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development. Development. 2023 Mar 1;150(5):dev201090
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7461267
Gene symbol: Dusp6
Gene name: dual specificity phosphatase 6
Antibody: anti-DUSP6 [EPR129Y] (ab76310)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 6C I: embryonic day 11.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/0 (more )
Note: Conditional mutant. Double labeled: green - Dusp6; red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS19: hindgut migratory enteric neural crest cell Present 6C I DUSP6 , 6C I merged DAPI , 6C I merged Expression in enteric neural crest-derived neurons (ENCDCs) at migratory wavefront.
TS19: midgut migratory enteric neural crest cell Present 6C I DUSP6 , 6C I merged DAPI , 6C I merged Expression in enteric neural crest-derived neurons (ENCDCs) at migratory wavefront.
Specimen 6C II: embryonic day 11.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/0 (more )
Note: Conditional mutant. Double labeled: green - Dusp6; red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS19: midgut migratory enteric neural crest cell Present 6C II DUSP6 , 6C II merged DAPI Expression in enteric neural crest-derived neurons (ENCDCs) at migratory wavefront.
TS19: hindgut migratory enteric neural crest cell Weak 6C II merged DAPI , 6C II DUSP6 Much lower expression in trailing region at E11.5.
Specimen 6D, 6E: embryonic day 13.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/0 (more )
Note: Conditional mutant. Double labeled: green - Dusp6; red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS21: hindgut migratory enteric neural crest cell Weak 6E DUSP6 , 6D DUSP6 Much lower expression in trailing region at E11.5.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory