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Gene Expression Data
Assay Details
Assay
Reference: J:333719 Hamada N, et al., Expression Analyses of Polo-Like Kinase 4, a Gene Product Responsible for Autosomal Recessive Microcephaly and Seckel Syndrome, during Mouse Brain Development. Dev Neurosci. 2022;44(6):643-650
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7444202
Gene symbol: Plk1
Gene name: polo like kinase 1
Antibody: anti-PLK1 (12952-4-AP)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2Aa/b: embryonic day 14.0 (more )
Structure Cell Type Level Pattern Image Note
TS22: cerebral cortex ventricular layer neural progenitor cell Present 2Ab , 2Aa Expression dominantly in progenitor cells in ventricular zone
Specimen 2Ac/e: embryonic day 14.0 (more )
Note: Double labeled: green - Plk1; red - Ctnnb1 (assay MGI:7444200).
Structure Level Pattern Image Note
TS22: cerebral cortex ventricular layer Present Regionally restricted 2Ac , 2Ae Expression co-localized with Ctnnb1 at ventricular zone surface; not enriched at centrosome.
Specimen 2Ba/b: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebral cortex cerebral cortex neuron Present Regionally restricted 2Ba , 2Bb Expression disappeared at ventricular surface. Expression diffusely distributed in cell body of cortical neurons.
Specimen 2Da: postnatal day 30 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present Regionally restricted 2Da Expression distributed in cytoplasm of Purkinje cells.
Specimen 2Db/b': postnatal day 30 (more )
Structure Level Pattern Image Note
TS28: cerebellum molecular layer Present 2Db , 2Db' Expression in molecular layer, which is composed of dendrites of Purkinje cells and axons of granule cells.
Specimen 2Dc/c': postnatal day 30 (more )
Structure Level Pattern Image Note
TS28: deep cerebellar nucleus Present Diffuse 2Dc' , 2Dc Expression diffusely distributed in cerebellar nuclei.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory