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Gene Expression Data
Assay Details
Assay
Reference: J:316179 Wang A, et al., An epigenetic circuit controls neurogenic programs during neocortex development. Development. 2021;148:dev199772
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7444001
Gene symbol: Mki67
Gene name: antigen identified by monoclonal antibody Ki 67
Results
Specimen S4A Ki67 WT: embryonic day 15.5 (more )
Note: Double labeled: red - Mki67; green - BrdU.
Structure Level Pattern Image Note
TS23: neocortex Present S4A WT Ki67 , S4A WT (enlarged) , S4A WT BrdU/Ki67 (upper) , S4A WT BrdU/Ki67 (lower)
Specimen S4A Ki67 KO: embryonic day 15.5; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Double labeled: red - Mki67; green - BrdU.
Structure Level Pattern Image Note
TS23: neocortex Present Regionally restricted S4A KO Ki67 , S4A KO BrdU/Ki67 (lower) , S4A KO (enlarged) , S4A KO BrdU/Ki67 (upper) Smaller proportion BrdU-labeled cells co-expressing Mki67
Specimen 3A Ki67 WT: embryonic day 16.5 (more )
Note: Triple labeled: blue/green - Mki67; red - Tbr2 (Eomes assay MGI:7444000); green - BrdU.
Structure Level Pattern Image Note
TS24: neocortex Present 3A WT TBR2/Ki67 , 3A WT TBR2/BrdU/Ki67 (enlarged) , 3A WT TBR2/BrdU/Ki67 (upper) , 3A WT TBR2/BrdU/Ki67 (lower)
Specimen 3A Ki67 KO: embryonic day 16.5; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Triple labeled: blue/green - Mki67; red - Tbr2 (Eomes assay MGI:7444000); green - BrdU.
Structure Level Pattern Image Note
TS24: neocortex Weak 3A KO TBR2/BrdU/Ki67 (lower) , 3A KO TBR2/BrdU/Ki67 (enlarged) , 3A KO TBR2/Ki67 , 3A KO TBR2/BrdU/Ki67 (upper) Fewer expressing cells compared to control. Fewer triple-labeled cells
Specimen S4E Ki67 WT: embryonic day 13.5 (more )
Note: Triple labeled: blue/green - Mki67; red - Tbr2 (Eomes assay MGI:7444000); green - BrdU.
Structure Level Pattern Image Note
TS21: neocortex Present S4E WT TBR2/BrdU/Ki67 , S4E WT Merge , S4E WT TBR2/Ki67
Specimen S4E Ki67 KO: embryonic day 13.5; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Triple labeled: blue/green - Mki67; red - Tbr2 (Eomes assay MGI:7444000); green - BrdU.
Structure Level Pattern Image Note
TS21: neocortex Present Regionally restricted S4E KO TBR2/BrdU/Ki67 , S4E KO Merge , S4E KO TBR2/Ki67 Significantly more cells co-expressing Tbr2 (Eomes).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
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