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Gene Expression Data
Assay Details
Assay
Reference: J:316179 Wang A, et al., An epigenetic circuit controls neurogenic programs during neocortex development. Development. 2021;148:dev199772
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7443999
Gene symbol: Pax6
Gene name: paired box 6
Results
Specimen 2D PAX6 WT: postnatal adult (more )
Note: Double labeled: green - Pax6; red - Tbr2 (Eomes assay MGI:7444000).
Structure Cell Type Level Pattern Image Note
TS28: neocortex forebrain radial glial cell Present 2D WT PAX6 , 2D WT (enlarged) , 2D WT PAX6/TBR2 Expression in radial glial cell progenitors.
Specimen 2D PAX6 KO: postnatal adult; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Double labeled: green - Pax6; red - Tbr2 (Eomes assay MGI:7444000).
Structure Cell Type Level Pattern Image Note
TS28: neocortex forebrain radial glial cell Present 2D KO PAX6 , 2D KO (enlarged) , 2D KO PAX6/TBR2 Expression not altered compared to wildtype.
Specimen S3E PAX6 WT: embryonic day 16.5 (more )
Note: Double labeled: green - Pax6; red - Tbr2 (Eomes assay MGI:7444000).
Structure Cell Type Level Pattern Image Note
TS24: neocortex forebrain radial glial cell Present S3E WT (left) , S3E WT (right) Expression in radial glial cell progenitors.
Specimen S3E PAX6 KO: embryonic day 16.5; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Double labeled: green - Pax6; red - Tbr2 (Eomes assay MGI:7444000).
Structure Cell Type Level Pattern Image Note
TS24: neocortex forebrain radial glial cell Present S3E KO (left) , S3E KO (right) Expression not altered, but more co-expression with Tbr2 (Eomes)
Specimen 2I PAX6 WT: embryonic day 13.5 (more )
Note: Double labeled: green - Pax6; red - Tbr2 (Eomes assay MGI:7444000).
Structure Cell Type Level Pattern Image Note
TS21: neocortex forebrain radial glial cell Present 2I WT PAX6/TBR2 , 2I WT PAX6 , 2I WT Merge Expression in radial glial cell progenitors.
Specimen 2I PAX6 KO: embryonic day 13.5; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Double labeled: green - Pax6; red - Tbr2 (Eomes assay MGI:7444000).
Structure Cell Type Level Pattern Image Note
TS21: neocortex forebrain radial glial cell Present 2I KO PAX6 , 2I KO PAX6/TBR2 , 2I KO Merge Slightly lower numbers of expressing cells, but increased co-expression with Tbr2 (Eomes).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
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