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Gene Expression Data
Assay Details
Assay
Reference: J:316179 Wang A, et al., An epigenetic circuit controls neurogenic programs during neocortex development. Development. 2021;148:dev199772
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7443995
Gene symbol: Satb2
Gene name: special AT-rich sequence binding protein 2
Results
Specimen 1A SATB2 WT: postnatal adult (more )
Note: Double labeled: red - Satb2; green - CTIP2 (Bcl11b assay MGI:7443994).
Structure Cell Type Level Pattern Image Note
TS28: neocortex pyramidal neuron Present Regionally restricted 1A WT CTIP2/SATP2 , 1A WT SATB2 Expression in upper layer projection neurons.
Specimen 1A SATB2 KO: postnatal adult; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Double labeled: red - Satb2; green - CTIP2 (Bcl11b assay MGI:7443994).
Structure Cell Type Level Pattern Image Note
TS28: neocortex pyramidal neuron Weak Regionally restricted 1A KO CTIP2/SATB2 , 1A KO SATB2 Significantly fewer upper layer projection neurons.
Specimen 1I SATB2 WT: postnatal day 7 (more )
Note: Double labeled: red - Satb2; green - BrdU.
Structure Cell Type Level Pattern Image Note
TS28: neocortex pyramidal neuron Present Regionally restricted 1I WT (right) , 1I WT (left) , 1I WT (inset) Many expressing cells labeled with with BrdU, properly localized.
Specimen 1I SATB2 KO: postnatal day 7; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Double labeled: red - Satb2; green - BrdU.
Structure Cell Type Level Pattern Image Note
TS28: neocortex pyramidal neuron Present Regionally restricted 1I KO (inset) , 1I KO (left) , 1I KO (right) Fewer projection neurons labeled with BrdU at E15.5, with larger proportion in deeper regions.
Specimen 2A SATB2 WT: embryonic day 16.5 (more )
Note: Double labeled: red - Satb2; green - CTIP2 (Bcl11b assay MGI:7443994).
Structure Cell Type Level Pattern Image Note
TS24: neocortex pyramidal neuron Present Regionally restricted 2A WT , 2A WT (enlarged) Expression in upper layer projection neurons.
Specimen 2A SATB2 KO: embryonic day 16.5; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Double labeled: red - Satb2; green - CTIP2 (Bcl11b assay MGI:7443994).
Structure Cell Type Level Pattern Image Note
TS24: neocortex pyramidal neuron Weak Regionally restricted 2A KO , 2A KO (enlarged) Fewer expressing cells compared to wildtype.
Specimen S3D SATB2 WT: embryonic day 16.5 (more )
Note: Double labeled: red - Satb2; green - CTIP2 (Bcl11b assay MGI:7443994).
Structure Cell Type Level Pattern Image Note
TS24: neocortex pyramidal neuron Present Regionally restricted S3D WT (left) , S3D WT (right) Expression in upper layer projection neurons.
Specimen S3D SATB2 KO: embryonic day 16.5; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Double labeled: red - Satb2; green - CTIP2 (Bcl11b assay MGI:7443994).
Structure Cell Type Level Pattern Image Note
TS24: neocortex pyramidal neuron Weak Regionally restricted S3D KO (right) , S3D KO (left) Fewer expressing cells compared to wildtype.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
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