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Gene Expression Data
Assay Details
Assay
Reference: J:316179 Wang A, et al., An epigenetic circuit controls neurogenic programs during neocortex development. Development. 2021;148:dev199772
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7443994
Gene symbol: Bcl11b
Gene name: B cell leukemia/lymphoma 11B
Results
Specimen 1A CTIP2 WT: postnatal adult (more )
Note: Double labeled: green - CTIP2 (Bcl11b); red - Satb2 (assay MGI:7443995).
Structure Cell Type Level Pattern Image Note
TS28: neocortex pyramidal neuron Present Regionally restricted 1A WT CTIP2/SATP2 , 1A WT CTIP2 Expression in upper layer projection neurons.
Specimen 1A CTIP2 KO: postnatal adult; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Double labeled: green - CTIP2 (Bcl11b); red - Satb2 (assay MGI:7443995).
Structure Cell Type Level Pattern Image Note
TS28: neocortex pyramidal neuron Present Regionally restricted 1A KO CTIP2 , 1A KO CTIP2/SATB2 Increased number of deep-layer projection neurons compared to wildtype, not statistically significant.
Specimen 1F CTIP2 WT: postnatal day 7 (more )
Note: Double labeled: red - CTIP (Bcl11b); green - BrdU.
Structure Cell Type Level Pattern Image Note
TS28: neocortex pyramidal neuron Present Regionally restricted 1F WT (right) , 1F WT (inset) , 1F WT (left) Expression in deep layer projection neurons. Many expressing cells labeled with with BrdU, properly localized.
Specimen 1F CTIP2 KO: postnatal day 7; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Double labeled: red - CTIP (Bcl11b); green - BrdU.
Structure Cell Type Level Pattern Image Note
TS28: neocortex pyramidal neuron Present Regionally restricted 1F KO (left) , 1F KO (inset) , 1F KO (right) More projection neurons labeled with BrdU at E13.5, with larger proportion in superficial regions.
Specimen 2A CTIP2 WT: embryonic day 16.5 (more )
Note: Double labeled: green - CTIP2 (Bcl11b); red - Satb2 (assay MGI:7443995).
Structure Cell Type Level Pattern Image Note
TS24: neocortex pyramidal neuron Present Regionally restricted 2A WT (enlarged) , 2A WT Expression in deep layer projection neurons.
Specimen 2A CTIP2 KO: embryonic day 16.5; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Double labeled: green - CTIP2 (Bcl11b); red - Satb2 (assay MGI:7443995).
Structure Cell Type Level Pattern Image Note
TS24: neocortex pyramidal neuron Present Regionally restricted 2A KO , 2A KO (enlarged) Expressing in projection neurons slightly over produced compared to wildtype.
Specimen S3D CTIP2 WT: embryonic day 16.5 (more )
Note: Double labeled: green - CTIP2 (Bcl11b); red - Satb2 (assay MGI:7443995).
Structure Cell Type Level Pattern Image Note
TS24: neocortex pyramidal neuron Present Regionally restricted S3D WT (right) , S3D WT (left) Expression in deep layer projection neurons.
Specimen S3D CTIP2 KO: embryonic day 16.5; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Note: Double labeled: green - CTIP2 (Bcl11b); red - Satb2 (assay MGI:7443995).
Structure Cell Type Level Pattern Image Note
TS24: neocortex pyramidal neuron Present Regionally restricted S3D KO (right) , S3D KO (left) Expressing in projection neurons slightly over produced compared to wildtype.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory