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Gene Expression Data
Assay Details
Assay
Reference: J:263835 Newman EA, et al., Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. Dev Biol. 2018 Jul 15;439(2):102-111
Assay type: RNA in situ
MGI Accession ID: MGI:7442814
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Probe: Isl1 probe
Probe preparation: Antisense RNA
Visualized with: Alkaline phosphatase
Results
Specimen 2B: embryonic day 12.5; Foxd1tm1(GFP/cre)Amc/Foxd1+ (more )
Structure Level Pattern Image Note
TS20: prethalamus Present 2B
TS20: hypothalamus Present Regionally restricted 2B Expressed in the ventral anterior hypothalamus.

Specimen 2C: embryonic day 12.5; Foxd1tm1(GFP/cre)Amc/Foxd1tm1(GFP/cre)Amc (more )
Structure Level Pattern Image Note
TS20: prethalamus Present 2C Similar as in the control.
TS20: hypothalamus Present Regionally restricted 2C Expressed in the ventral anterior hypothalamus, similar as in the control.

Specimen 4H: embryonic day 16.5; Foxd1tm1(GFP/cre)Amc/Foxd1+ (more )
Structure Level Pattern Image Note
TS24: hypothalamus Present Regionally restricted 4H Broadly expressed in anterior hypothalamus.

Specimen 4I: embryonic day 16.5; Foxd1tm1(GFP/cre)Amc/Foxd1tm1(GFP/cre)Amc (more )
Structure Level Pattern Image Note
TS24: anterior hypothalamic nucleus Present Regionally restricted 4I Broadly expressed in anterior hypothalamus. The expression domain was significantly more medial and located close to the third ventricle.

Specimen 5U: postnatal day 0; Foxd1tm1(GFP/cre)Amc/Foxd1+ (more )
Structure Level Pattern Image Note
TS27: hypothalamus periventricular zone Present 5U
TS27: prethalamus Present 5U
TS27: suprachiasmatic nucleus Present 5U

Specimen 5V: postnatal day 0; Foxd1tm1(GFP/cre)Amc/Foxd1tm1(GFP/cre)Amc (more )
Structure Level Pattern Image Note
TS27: prethalamus Present 5V Similar as in the control.
TS27: hypothalamus periventricular zone Weak 5V Severely disrupted expression.
TS27: suprachiasmatic nucleus Weak 5V Severely disrupted expression.

Specimen 6A: postnatal day 0; Foxd1tm1(GFP/cre)Amc/Foxd1+ (more )
Structure Level Pattern Image Note
TS27: arcuate nucleus Present 6A
TS27: dorsomedial hypothalamic nucleus Present 6A
TS27: lateral hypothalamic area Present 6A
TS27: ventromedial hypothalamic nucleus Present 6A

Specimen 6B: postnatal day 0; Foxd1tm1(GFP/cre)Amc/Foxd1tm1(GFP/cre)Amc (more )
Structure Level Pattern Image Note
TS27: arcuate nucleus Absent 6B
TS27: dorsomedial hypothalamic nucleus Weak 6B Reduced expression compared with the control.
TS27: lateral hypothalamic area Weak 6B Reduced expression compared with the control.
TS27: ventromedial hypothalamic nucleus Weak 6B Reduced expression compared with the control.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory