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Gene Expression Data
Assay Details
Assay
Reference: J:326689 Phan TP, et al., Upstream open reading frames control PLK4 translation and centriole duplication in primordial germ cells. Genes Dev. 2022 Jun 1;36(11-12):718-736
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7442639
Gene symbol: Dazl
Gene name: deleted in azoospermia-like
Antibody: Anti-DAZL [EPR21028] (ab215718)
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen 3E +/+: postnatal day 28 (more )
Note: Double labeled: red - Dazl; yellow - Sycp3 (assay MGI:7442637).
Structure Level Pattern Image Note
TS28: spermatogonium Present 3E +/+ , 3E +/+ DAZL
Specimen 3E deltau/deltau: postnatal day 28; Plk4em1Ahol/Plk4em1Ahol (more )
Note: Double labeled: red - Dazl; yellow - Sycp3 (assay MGI:7442637).
Structure Level Pattern Image Note
TS28: spermatogonium Present 3E deltau/deltau 2 DAZL , 3E deltau/deltau 1 DAZL , 3E deltau/deltau A severe reduction in Sycp3- Dazl+ premeiotic germ cells, and no enrichment for meiotically arrested cells, compared with the wild-type.
Specimen 3H +/+: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: spermatogonium Present 3H +/+
Specimen 3H deltau/deltau: postnatal day 0; Plk4em1Ahol/Plk4em1Ahol (more )
Structure Level Pattern Image Note
TS27: spermatogonium Present 3H deltau/deltau A severe depletion of tubules containing positive germ cells.
Specimen 5G +/+: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: spermatogonium Present 5G +/+
Specimen 5G deltau/-: postnatal day 0; Plk4em1Ahol/Plk4em2.1Ahol (more )
Structure Level Pattern Image Note
TS27: spermatogonium Present 5G deltau/- Rescued germ cell number was seen.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory