Tg(IghARS)820Fnp
Transgene Detail
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| Symbol: |
Tg(IghARS)820Fnp |
| Name: |
transgene insertion 820, F Nina Papavasiliou |
| MGI ID: |
MGI:7438212 |
| Synonyms: |
820 |
| Transgene: |
Tg(IghARS)820Fnp Location: unknown
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| Alliance: |
Tg(IghARS)820Fnp page
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| Strain of Origin: |
(C57BL/6 x SJL)F2
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| Transgene Type: |
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Transgenic (Conditional ready, Epitope tag, Inserted expressed sequence, Modified regulatory region) |
| Mutation: |
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Insertion
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Mutation details: The transgene comprises a 129 strain-derived (Igha haplotype) BAC, containing an anti-arsonate (ARS) re-arranged VDJ region plus all S regions and C segments and the 3'RR super-enhancer (Rr152), that was modified as follows: two copies of chicken beta-globin genomic insulator sequence were inserted upstream of the Igh cluster, 4-bp sequences were inserted in the Ighg1 and Ighg2a genes (to distinguish transgene transcripts from endogenous transcripts), FLAG tag encoding sequence was inserted at the 3' end of the secreted isoform of Ighg2a, and loxP sites were inserted up- and downstream of Rr152.
(J:155457)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:155457 Dunnick WA, et al., Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region. J Exp Med. 2009 Nov 23;206(12):2613-23 |
| All: |
2 reference(s) |
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Analysis Tools
