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Gene Expression Data
Assay Details
Assay
Reference: J:237224 Kim JY, et al., Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye. Dev Biol. 2016 Nov 15;419(2):336-347
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7437618
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175; #9661)
Detection system: Secondary antibody coupled to Cy5
Results
Specimen 6A: embryonic day 15.5; Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Structure Level Pattern Image Note
TS23: neural retina Present Single cells 6A Few positive cells.
Specimen 6B: embryonic day 15.5; Tg(rx3-icre)1Mjam/0, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: neural retina Present Single cells 6B Few positive cells, similar as in the wild-type.
Specimen 6C: embryonic day 16.5; Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Double labeled: red - Casp3; green - Yap1 (assay MGI:7437575).
Structure Level Pattern Image Note
TS24: neural retina Present Single cells 6C
Specimen 6D: embryonic day 16.5; Tg(rx3-icre)1Mjam/0, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Yap1 (assay MGI:7437575).
Structure Level Pattern Image Note
TS24: neural retina Present Single cells 6D More positive cells were detected in the epithelial areas where Yap1 reduction was evident.
Specimen 6E/G: postnatal day 0; Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Double labeled: red - Casp3; green - Yap1 (assay MGI:7437575).
Structure Level Pattern Image Note
TS27: neural retina Present 6G , 6E Few positive cells.
Specimen 6H/J: postnatal day 0; Tg(rx3-icre)1Mjam/0, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Yap1 (assay MGI:7437575).
Structure Level Pattern Image Note
TS27: neural retina Present Scattered 6J , 6H Dramatic and widespread increase (25 fold) of positive cells occurred preferentially in the mutant epithelial area without Yap1 staining in both inner and outer neuroblastic layer.
Specimen 7A: postnatal day 0; Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Double labeled: red - Casp3; green - Pcna (assay MGI:7437619).
Structure Level Pattern Image Note
TS27: neural retina Present Single cells 7A Few positive cells.
Specimen 7B: postnatal day 0; Tg(rx3-icre)1Mjam/0, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Pcna (assay MGI:7437619).
Structure Level Pattern Image Note
TS27: neural retina Present Scattered 7B Increased expression, but rarely costained with Pcna.
Specimen 7C: postnatal day 0; Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Double labeled: red - Casp3; green - Vsx2 (assay MGI:7437620).
Structure Level Pattern Image Note
TS27: neural retina Present Single cells 7C Few positive cells.
Specimen 7D: postnatal day 0; Tg(rx3-icre)1Mjam/0, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Vsx2 (assay MGI:7437620).
Structure Level Pattern Image Note
TS27: neural retina Present Scattered 7D Increased expression, but rarely costained with Vsx2.
Specimen 7E: postnatal day 0; Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Double labeled: red - Casp3; green - Cdkn1b (assay MGI:7437621).
Structure Level Pattern Image Note
TS27: neural retina Present Single cells 7E Few positive cells.
Specimen 7F: postnatal day 0; Tg(rx3-icre)1Mjam/0, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Cdkn1b (assay MGI:7437621).
Structure Level Pattern Image Note
TS27: neural retina Present Scattered 7F Increased expression, but rarely costained with Cdkn1b.
Specimen 7G: postnatal day 0; Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Double labeled: red - Casp3; green - Pax6 (assay MGI:7437622).
Structure Level Pattern Image Note
TS27: neural retina Present Single cells 7G Few positive cells.
Specimen 7H: postnatal day 0; Tg(rx3-icre)1Mjam/0, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Pax6 (assay MGI:7437622).
Structure Level Pattern Image Note
TS27: neural retina Present Scattered 7H Increased expression, but rarely costained with Pax6.
Specimen 7I: postnatal day 0; Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Double labeled: red - Casp3; green - Rho (assay MGI:7437623).
Structure Level Pattern Image Note
TS27: neural retina Present Single cells 7I Few positive cells.
Specimen 7J: postnatal day 0; Tg(rx3-icre)1Mjam/0, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - Rho (assay MGI:7437623).
Structure Level Pattern Image Note
TS27: neural retina Present Scattered 7J Increased expression, but rarely costained with Rho.
Specimen 7K: postnatal day 0; Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Double labeled: red - Casp3; green - BrdU.
Structure Level Pattern Image Note
TS27: neural retina Present Single cells 7K Few positive cells.
Specimen 7L: postnatal day 0; Tg(rx3-icre)1Mjam/0, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant. Double labeled: red - Casp3; green - BrdU.
Structure Level Pattern Image Note
TS27: neural retina Present Scattered 7L Increased expression, but rarely costained with BrdU.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory