About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:233405 Lee J, et al., Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit. Front Cell Neurosci. 2015;9:94
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7431002
Gene symbol: Shank3
Gene name: SH3 and multiple ankyrin repeat domains 3
Reporter: Beta-geo
Direct Detection
Results
Specimen 2C upper: postnatal week 6-7; Shank3tm1a(KOMP)Mbp/Shank3+ (more )
Note: sagittal section
Structure Level Pattern Image Note
TS28: cerebral cortex Strong 2C upper
TS28: corpus striatum Strong 2C upper
TS28: thalamus Strong 2C upper
TS28: cerebellum Absent 2C upper
TS28: main olfactory bulb Absent 2C upper
TS28: dentate gyrus Strong 2C upper Expression was stronger than in CA3.
TS28: hippocampus CA1 Strong 2C upper Expression was stronger than in CA3.
TS28: hippocampus CA3 Present 2C upper
Specimen 2C lower: postnatal week 6-7; Shank3tm1a(KOMP)Mbp/Shank3+ (more )
Note: coronal section
Structure Level Pattern Image Note
TS28: cerebral cortex Strong 2C lower
TS28: corpus striatum Strong 2C lower
TS28: thalamus Strong 2C lower
TS28: cerebellum Absent 2C lower
TS28: main olfactory bulb Absent 2C lower
TS28: dentate gyrus Strong 2C lower Expression was stronger than in CA3.
TS28: hippocampus CA1 Strong 2C lower Expression was stronger than in CA3.
TS28: hippocampus CA3 Present 2C lower
Specimen S1A: postnatal week 6-7; Shank3tm1a(KOMP)Mbp/Shank3+ (more )
Note: coronal section
Structure Level Pattern Image Note
TS28: cerebral cortex Strong S1 pp. 1
TS28: corpus striatum Strong S1 pp. 1
TS28: thalamus Strong S1 pp. 1
TS28: cerebellum Absent S1 pp. 1
TS28: main olfactory bulb Absent S1 pp. 1
Specimen S1B: postnatal week 6-7; Shank3tm1a(KOMP)Mbp/Shank3+ (more )
Note: coronal section
Structure Level Pattern Image Note
TS28: cerebral cortex Strong S1 pp. 2
TS28: corpus striatum Strong S1 pp. 2
TS28: thalamus Strong S1 pp. 2
TS28: cerebellum Absent S1 pp. 2
TS28: main olfactory bulb Absent S1 pp. 2
TS28: dentate gyrus Strong S1 pp. 2 Expression was stronger than in CA3.
TS28: hippocampus CA1 Strong S1 pp. 2 Expression was stronger than in CA3.
TS28: hippocampus CA3 Present S1 pp. 2
Specimen S1C: postnatal week 6-7; Shank3tm1a(KOMP)Mbp/Shank3+ (more )
Note: coronal section
Structure Level Pattern Image Note
TS28: cerebral cortex Strong S1 pp. 3
TS28: corpus striatum Strong S1 pp. 3
TS28: thalamus Strong S1 pp. 3
TS28: cerebellum Absent S1 pp. 3
TS28: main olfactory bulb Absent S1 pp. 3
TS28: dentate gyrus Strong S1 pp. 3 Expression was stronger than in CA3.
TS28: hippocampus CA1 Strong S1 pp. 3 Expression was stronger than in CA3.
TS28: hippocampus CA3 Present S1 pp. 3
Specimen S2: postnatal week 6-7; Shank3tm1a(KOMP)Mbp/Shank3+ (more )
Note: coronal section
Structure Level Pattern Image Note
TS28: cortical layer II Strong S2 Expression was stronger than those in layers 5 and 6.
TS28: cortical layer III Strong S2 Expression was stronger than those in layers 5 and 6.
TS28: cortical layer IV Strong S2 Expression was stronger than those in layers 5 and 6.
TS28: cortical layer VI Present S2
TS28: cortical layer I Absent S2
TS28: cortical layer V Weak S2
Specimen not shown: postnatal week 6-7; Shank3tm1a(KOMP)Mbp/Shank3+ (more )
Note: Data was summarized in Table 1.
Structure Level Pattern Image Note
TS28: globus pallidus Absent
TS28: habenula Absent
TS28: hypothalamus Absent
TS28: reticular thalamic nucleus Absent
TS28: substantia nigra Absent
TS28: ventral tegmental area Absent
TS28: caudate-putamen Strong
TS28: amygdala Present
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory