About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:120320 Shih HP, et al., Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5907-12
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7430779
Gene symbol: Tcf21
Gene name: transcription factor 21
Antibody: Anti-Tcf21
Results
Specimen 2S: embryonic day 10.5; Pitx2tm1Rsd/Pitx2+, H2az2Tg(Wnt1-cre)11Rth/0, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: red - Tcf21; blue - Pitx2 reporter (assay MGI:7430765); green - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS17: 1st branchial arch mesenchyme Present Regionally restricted 2S , 2T Pitx2(beta-gal) and Tcf21 are co-expressed in the mesodermal cores of the first and second branchial arches.
TS17: 2nd branchial arch mesenchyme Present Regionally restricted 2S , 2T Pitx2(beta-gal) and Tcf21 are co-expressed in the mesodermal cores of the first and second branchial arches.
TS17: 1st branchial arch mesenchyme neural crest cell Present Regionally restricted 2T , 2S A Tcf21+/Pitx2(beta-gal)- neural crest cell population was detected in the mesoderm core of the first branchial arch.
Specimen 2W: embryonic day 10.5; Pitx2tm1Rsd/Pitx2tm1Rsd, H2az2Tg(Wnt1-cre)11Rth/0, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Triple labeled: red - Tcf21; blue - Pitx2 reporter (assay MGI:7430765); green - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS17: 1st branchial arch mesenchyme neural crest cell Present Regionally restricted 2X , 2W Only Tcf21+ cells of the neural crest lineage were labeled. No Tcf21+/Pitx2(beta-gal)+ cells were detected in the first branchial arch.
TS17: 2nd branchial arch mesenchyme Present Regionally restricted 2X , 2W The Pitx2(beta-gal)+/Tcf1+ cell population in the second branchial arch showed no significant difference in size.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory