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Gene Expression Data
Assay Details
Assay
Reference: J:284573 Gao XL, et al., High-mobility group nucleosomal binding domain 2 protects against microcephaly by maintaining global chromatin accessibility during corticogenesis. J Biol Chem. 2020 Jan 10;295(2):468-480
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7428968
Gene symbol: Bcl11b
Gene name: B cell leukemia/lymphoma 11B
Antibody: anti-CTIP2 [25B6] (ab18465)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 3A WT: postnatal day 14 (more )
Note: Triple labeled: green - Bcl11b; red - Cux1 (assay MGI:7428967); gray - Satb2 (assay MGI:7428969).
Structure Cell Type Level Pattern Image Note
TS28: cortical layer V cerebral cortex neuron Present 3A WT merge , 3A WT Ctip2
TS28: cortical layer VI cerebral cortex neuron Present 3A WT merge , 3A WT Ctip2
Specimen 3A mKO: postnatal day 14; Hmgn2tm1a(KOMP)Wtsi/Hmgn2tm1a(KOMP)Wtsi (more )
Note: Triple labeled: green - Bcl11b; red - Cux1 (assay MGI:7428967); gray - Satb2 (assay MGI:7428969).
Structure Cell Type Level Pattern Image Note
TS28: cortical layer V cerebral cortex neuron Present 3A mKO Ctip2 , 3A mKO merge The distribution of immunolabeled neurons was similar to the wild type.
TS28: cortical layer VI cerebral cortex neuron Present 3A mKO Ctip2 , 3A mKO merge The distribution of immunolabeled neurons was similar to the wild type.
Specimen 4E WT: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: cerebral cortex cerebral cortex neuron Present Regionally restricted 4E WT Expression was detected in the deeper-layer neurons.
Specimen 4E mKO: embryonic day 18.5; Hmgn2tm1a(KOMP)Wtsi/Hmgn2tm1a(KOMP)Wtsi (more )
Structure Cell Type Level Pattern Image Note
TS26: cerebral cortex cerebral cortex neuron Present Regionally restricted 4E mKO The number of immunolabeled deeper-layer neurons decreased in the mutant compared with wild type.
Specimen 4G WT: embryonic day 18.5 (more )
Note: Triple labeled: gray - Bcl11b; red - Pax6 (assay MGI:7428971); green - Eomes (assay MGI:7428954).
Structure Cell Type Level Pattern Image Note
TS26: cerebral cortex cerebral cortex neuron Present Regionally restricted 4G WT Expression was detected in the deeper-layer neurons.
Specimen 4G mKO: embryonic day 18.5; Hmgn2tm1a(KOMP)Wtsi/Hmgn2tm1a(KOMP)Wtsi (more )
Note: Triple labeled: gray - Bcl11b; red - Pax6 (assay MGI:7428971); green - Eomes (assay MGI:7428954).
Structure Cell Type Level Pattern Image Note
TS26: cerebral cortex cerebral cortex neuron Present Regionally restricted 4G mKO The number of immunolabeled deeper-layer neurons decreased in the mutant compared with wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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