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Gene Expression Data
Assay Details
Assay
Reference: J:332497 Tang X, et al., EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly. iScience. 2023 Jan 20;26(1):105667
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7427874
Gene symbol: Emc3
Gene name: ER membrane protein complex subunit 3
Antibody: anti-EMC3 (HPA042372)
Assay notes: Three antibodies were described, but the one used in this assay was not detailed. Anti-TM111 (702736) MGI:7427869 or anti-TMEM111 [A-12] (sc-365903) MGI:6456889 may have been used in this assay.
Results
Specimen 1E control: embryonic day 18.5; Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi (more )
Structure Level Pattern Image Note
TS26: lung epithelium Present Widespread 1E control Widespread expression in epithelial and mesenchymal cells.
TS26: lung mesenchyme Present Widespread 1E control Widespread expression in epithelial and mesenchymal cells.
Specimen 1E Emc3 cKO: embryonic day 18.5; Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi, Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: lung mesenchyme Present 1E Emc3 cKO Authors report expression partially recovered in lung mesenchyme at E18.5.
Specimen 1F control: embryonic day 16.5; Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi (more )
Structure Level Pattern Image Note
TS24: lung mesenchyme Present 1F control
Specimen 1F Emc3 cKO: embryonic day 16.5; Emc3tm1c(EUCOMM)Wtsi/Emc3tm1c(EUCOMM)Wtsi, Twist2tm1.1(cre)Dor/Twist2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: lung mesenchyme Weak 1F Emc3 cKO Expression decreased in lung mesenchyme compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory