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Gene Expression Data
Assay Details
Assay
Reference: J:266596 Kersbergen A, et al., Lung morphogenesis is orchestrated through Grainyhead-like 2 (Grhl2) transcriptional programs. Dev Biol. 2018 Nov 1;443(1):1-9
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7427504
Gene symbol: Pdpn
Gene name: podoplanin
Antibody: Anti-Podoplanin (clone 8.1.1)
Detection system: Secondary antibody coupled to Alexa Fluor 647
Results
Specimen Grhl2 delta/+: embryonic day 18.5; Grhl2tm2.1Jane/Grhl2+, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Data was not shown, and quantified in Fig 2C.
Structure Cell Type Level Pattern Image Note
TS26: alveolus epithelium type I pneumocyte Present
Specimen Grhl2 delta/-: embryonic day 18.5; Grhl2tm1.1Jane/Grhl2tm2.1Jane, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant. Data was not shown, and quantified in Fig 2C.
Structure Cell Type Level Pattern Image Note
TS26: alveolus epithelium type I pneumocyte Present Significant reduction in the saccule size in the mutant compared with the control.
Specimen 3K: embryonic day 18.5; Grhl2tm2.1Jane/Grhl2+, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: alveolus epithelium type I pneumocyte Present 3K
Specimen 3L: embryonic day 18.5; Grhl2tm1.1Jane/Grhl2tm2.1Jane, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: alveolus epithelium type I pneumocyte Present 3L No apparent change in the number of the positive cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory