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Gene Expression Data
Assay Details
Assay
Reference: J:268254 Rich CA, et al., Olfactory ensheathing cells abutting the embryonic olfactory bulb express Frzb, whose deletion disrupts olfactory axon targeting. Glia. 2018 Dec;66(12):2617-2631
Assay type: RNA in situ
MGI Accession ID: MGI:7427354
Gene symbol: Frzb
Gene name: frizzled-related protein
Probe: Frzb cDNA3
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen Not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS18: 1st branchial arch mandibular component mesenchyme Present Expression is seen in the mesenchyme of the prominences.
TS18: 1st branchial arch maxillary component mesenchyme Present Expression is seen in the mesenchyme of the prominences.
TS18: olfactory system Absent
Specimen 1a: embryonic day 11.5 (more )
Note: Parasagittal section. Triple labeled: purple - Frzb; green - Sox10 protein (assay MGI:7427400); magenta - Tubb3 (assay MGI:7427402).
Structure Cell Type Level Pattern Image Note
TS20: mandibular process mesenchyme Present 1a Expression is in the prominence.
TS20: maxillary process mesenchyme Present 1a Expression is in the prominence.
TS20: fronto-nasal process mesenchyme Present Regionally restricted 1a Expression is the fronto-nasal mesenchyme caudal to the olfactory epithelium.
TS20: olfactory nerve olfactory ensheathing cell Absent 1c3 , 1c1 , 1c2 , 1b , 1a There is no expression in the OECs associated with olfactory nerve fascicles.
Specimen 1d: embryonic day 13.5 (more )
Note: Parasagittal section. Triple labeled: purple - Frzb; green - Sox10 protein (assay MGI:7427400); magenta - Tubb3 (assay MGI:7427402).
Structure Cell Type Level Pattern Image Note
TS22: main olfactory bulb olfactory nerve layer olfactory ensheathing cell Strong 1g2 , 1e , 1f1 , 1f3 , 1g1 , 1g , 1f2 , 1d Expression can be seen in a subset of OECs in the olfactory nerve layer adjacent to the olfactory bulb.
TS22: olfactory nerve olfactory ensheathing cell Present Single cells 1h1 , 1h2 , 1g1 , 1g , 1g2 , 1h , 1e , 1d Expression can be seen in a few OECs on the olfactory nerve.
Specimen 2a: embryonic day 16.5 (more )
Note: Parasagittal section. Triple labeled: purple - Frzb; green - Sox10 protein (assay MGI:7427400); magenta - Tubb3 (assay MGI:7427402).
Structure Cell Type Level Pattern Image Note
TS24: main olfactory bulb olfactory nerve layer olfactory ensheathing cell Present Non-Uniform 2b , 2b2 , 2b1 , 2a The inner OECs show stronger expression than the outer ones.
TS24: olfactory nerve olfactory ensheathing cell Present Single cells 2c3 , 2c2 , 2a , 2c1 Expression is seen in a few OECs associated with peripheral olfactory nerve fascicles.
Specimen 3a: embryonic day 13.5 (more )
Note: Coronal section. Triple labeled: purple - Frzb; green - Sox10 protein (assay MGI:7427400); magenta - Tubb3 (assay MGI:7427402).
Structure Cell Type Level Pattern Image Note
TS22: main olfactory bulb olfactory nerve layer olfactory ensheathing cell Present 3d2 , 3c1 , 3d1 , 3d , 3b , 3a
Specimen 3e: embryonic day 13.5; Sox10tm1Weg/Sox10tm1Weg (more )
Note: Coronal section. Triple labeled: purple - Frzb; green - Sox10 reporter (assay MGI:7427366); magenta - Tubb3 (assay MGI:7427402).
Structure Cell Type Level Pattern Image Note
TS22: main olfactory bulb olfactory nerve layer olfactory ensheathing cell Absent 3h1 , 3h2 , 3h , 3e , 3f , 3g1
Specimen 3i: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS22: upper jaw mesenchyme Present 3j , 3i
TS22: lower jaw mesenchyme Present 3k , 3i
Specimen 3l: embryonic day 13.5; Sox10tm1Weg/Sox10tm1Weg (more )
Structure Level Pattern Image Note
TS22: upper jaw mesenchyme Present 3l , 3m
TS22: lower jaw mesenchyme Present 3l , 3n
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory