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Gene Expression Data
Assay Details
Assay
Reference: J:290961 Chen F, et al., YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells. EMBO J. 2019 May 15;38(10)
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7408312
Gene symbol: Pax7
Gene name: paired box 7
Antibody: anti-Pax7
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to Cy3
Results
Specimen 1B Ctrl: embryonic day 12.5; Yy1tm2.1Yshi/Yy1+ (more )
Note: Double labeled: red - Pax7; green - Yy1 (assay MGI:7408313).
Structure Cell Type Level Pattern Image Note
TS20: myotome muscle precursor cell Present 1B Ctrl Pax7 , 1B Ctrl merge
Specimen 1B cKO: embryonic day 12.5; Pax7tm1(cre)Mrc/Pax7+, Yy1tm2.1Yshi/Yy1tm2.1Yshi (more )
Note: Conditional mutant. Double labeled: red - Pax7; green - Yy1 (assay MGI:7408313).
Structure Cell Type Level Pattern Image Note
TS20: myotome muscle precursor cell Present 1B cKO Pax7 , 1B cKO merge
Specimen 1C Ctrl: embryonic day 12.5; Yy1tm2.1Yshi/Yy1+ (more )
Note: Double labeled: red - Pax7; green - Yy1 (assay MGI:7408313).
Structure Cell Type Level Pattern Image Note
TS20: limb musculature skeletal muscle myoblast Present 1C Ctrl merge , 1C Ctrl Pax7
Specimen 1C cKO: embryonic day 12.5; Pax7tm1(cre)Mrc/Pax7+, Yy1tm2.1Yshi/Yy1tm2.1Yshi (more )
Note: Conditional mutant. Double labeled: red - Pax7; green - Yy1 (assay MGI:7408313).
Structure Cell Type Level Pattern Image Note
TS20: limb musculature skeletal muscle myoblast Present 1C cKO Pax7 , 1C cKO merge
Specimen 1N Ctrl: embryonic day 18.5; Yy1tm2.1Yshi/Yy1+ (more )
Note: Double labeled: red - Pax7; green - Laminin staining.
Structure Cell Type Level Pattern Image Note
TS26: hindlimb muscle muscle precursor cell Present 1N Ctrl
Specimen 1N cKO: embryonic day 18.5; Pax7tm1(cre)Mrc/Pax7+, Yy1tm2.1Yshi/Yy1tm2.1Yshi (more )
Note: Conditional mutant. Double labeled: red - Pax7; green - Laminin staining.
Structure Cell Type Level Pattern Image Note
TS26: hindlimb muscle muscle precursor cell Present 1N cKO Marked decrease in the number of positive cells compared with the control.
Specimen 1O Ctrl: embryonic day 18.5; Yy1tm2.1Yshi/Yy1+ (more )
Note: Double labeled: red - Pax7; green - Laminin staining.
Structure Cell Type Level Pattern Image Note
TS26: diaphragm muscle precursor cell Present 1O Ctrl
Specimen 1O cKO: embryonic day 18.5; Pax7tm1(cre)Mrc/Pax7+, Yy1tm2.1Yshi/Yy1tm2.1Yshi (more )
Note: Conditional mutant. Double labeled: red - Pax7; green - Laminin staining.
Structure Cell Type Level Pattern Image Note
TS26: diaphragm muscle precursor cell Present 1O cKO Marked decrease in the number of positive cells compared with the control.
Specimen EV1D Ctrl: embryonic day 12.5; Yy1tm2.1Yshi/Yy1+ (more )
Structure Cell Type Level Pattern Image Note
TS20: myotome muscle precursor cell Present EV1D upper left
Specimen EV1D cKO: embryonic day 12.5; Pax7tm1(cre)Mrc/Pax7+, Yy1tm2.1Yshi/Yy1tm2.1Yshi (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: myotome muscle precursor cell Present EV1D lower left Similar as in the control.
Specimen EV1E Ctrl: embryonic day 14.5; Yy1tm2.1Yshi/Yy1+ (more )
Structure Cell Type Level Pattern Image Note
TS22: hindlimb muscle muscle precursor cell Present EV1E upper right , EV1E upper left
Specimen EV1E cKO: embryonic day 14.5; Pax7tm1(cre)Mrc/Pax7+, Yy1tm2.1Yshi/Yy1tm2.1Yshi (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS22: hindlimb muscle muscle precursor cell Present EV1E lower left , EV1E lower right Marked decrease (35%) in the number of positive cells compared with the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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