Sox2 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:226736 Li X, et al., Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus. Antioxid Redox Signal. 2014 Oct 20;21(12):1675-92
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7384769
Gene symbol:	Sox2
Gene name:	SRY (sex determining region Y)-box 2

Antibody:	anti-Sox2
Detection system:	Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase

Results

Specimen 2A +/+: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: telencephalon subventricular zone	Present		2A Sox2 Foxo3a^+/+;Fancd2^+/+	Expression is in neural stem and progenitor cells.
TS21: telencephalon ventricular layer	Present		2A Sox2 Foxo3a^+/+;Fancd2^+/+	Expression is in neural stem and progenitor cells.

Specimen 2A Fancd2^-/-: embryonic day 13.5; Fancd2^tm1Hou/Fancd2^tm1Hou (more

)

Structure	Level	Pattern	Image	Note
TS21: telencephalon subventricular zone	Present		2A Sox2 Foxo3a^+/+;Fancd2^-/-	Expression is in neural stem and progenitor cells.
TS21: telencephalon ventricular layer	Present		2A Sox2 Foxo3a^+/+;Fancd2^-/-	Expression is in neural stem and progenitor cells.

Specimen 2A Foxo3a^-/-: embryonic day 13.5; Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp (more

)

Structure	Level	Pattern	Image	Note
TS21: telencephalon subventricular zone	Present		2A Sox2 Foxo3a^-/-;Fancd2^+/+	Expression is in neural stem and progenitor cells.
TS21: telencephalon ventricular layer	Present		2A Sox2 Foxo3a^-/-;Fancd2^+/+	Expression is in neural stem and progenitor cells.

Specimen 2A DKO: embryonic day 13.5; Fancd2^tm1Hou/Fancd2^tm1Hou, Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp (more

)

Structure	Level	Pattern	Image	Note
TS21: telencephalon subventricular zone	Present		2A Sox2 Foxo3a^-/-;Fancd2^-/-	The number of neural stem and progenitor cells in this mutant was significantly decreased compared with that of wild type.
TS21: telencephalon ventricular layer	Present		2A Sox2 Foxo3a^-/-;Fancd2^-/-	The number of neural stem and progenitor cells in this mutant was significantly decreased compared with that of wild type.

Specimen 5C +/+: postnatal week 8 (more

)

Structure	Level	Pattern	Image	Note
TS28: telencephalon subventricular zone	Present	Regionally restricted	5C Foxo3a^+/+;Fancd2^+/+	Expression is in neural stem and progenitor cells.

Specimen 5C DKO: postnatal week 8; Fancd2^tm1Hou/Fancd2^tm1Hou, Foxo3^tm1.1Rdp/Foxo3^tm1.1Rdp (more

)

Structure	Level	Pattern	Image	Note
TS28: telencephalon subventricular zone	Present	Regionally restricted	5C Foxo3a^-/-;Fancd2^-/-	The number of neural stem and progenitor cells in this mutant was significantly decreased compared with that of wild type.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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