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Gene Expression Data
Assay Details
Assay
Reference: J:158583 Ko HW, et al., Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev Cell. 2010 Feb 16;18(2):237-47
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7380666
Gene symbol: Foxa2
Gene name: forkhead box A2
Antibody: 4C7
Detection system: Secondary antibody
Results
Specimen 1A FoxA2 WT: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: neural tube floor plate Present 1A FoxA2 WT

Specimen 1A FoxA2 bromi: embryonic day 10.5; Tbc1d32bromi/Tbc1d32bromi (more )
Structure Level Pattern Image Note
TS17: neural tube Absent 1A FoxA2 bromi

Specimen 2 FoxA2 WT: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: neural tube floor plate Present 2_FoxA2 WT

Specimen 2 FoxA2 bromi: embryonic day 9.5; Tbc1d32bromi/Tbc1d32bromi (more )
Structure Level Pattern Image Note
TS15: neural tube Absent 2_FoxA2 bromi

Specimen 2 FoxA2 Ptch1: embryonic day 9.5; Ptch1tm1Mps/Ptch1tm1Mps (more )
Structure Level Pattern Image Note
TS15: neural tube Present Widespread 2_FoxA2 Ptch1 Broadly expressed throughout open neural tube.

Specimen 2 FoxA2 bromi,Ptch1: embryonic day 9.5; Ptch1tm1Mps/Ptch1tm1Mps, Tbc1d32bromi/Tbc1d32bromi (more )
Structure Level Pattern Image Note
TS15: neural tube Absent 2_FoxA2 bromi,Ptch1

Specimen 3A FoxA2 WT: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: neural tube floor plate Present 3A FoxA2 WT

Specimen 3A FoxA2 bromi: embryonic day 10.5; Tbc1d32bromi/Tbc1d32bromi (more )
Structure Level Pattern Image Note
TS17: neural tube Absent 3A FoxA2 bromi

Specimen 3A FoxA2 Gli3xt: embryonic day 10.5; Gli3Xt-J/Gli3Xt-J (more )
Structure Level Pattern Image Note
TS17: neural tube floor plate Present 3A FoxA2 Gli3xt Authors report normal expression.

Specimen 3A FoxA2 bromi,Gli3xt: embryonic day 10.5; Gli3Xt-J/Gli3Xt-J, Tbc1d32bromi/Tbc1d32bromi (more )
Structure Level Pattern Image Note
TS17: neural tube Present Regionally restricted 3A FoxA2 bromi,Gli3xt Authors report disruption of floor plate specification.

Specimen 3B FoxA2 WT: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: neural tube floor plate Present 3B FoxA2 WT

Specimen 3B FoxA2 bromi: embryonic day 10.5; Tbc1d32bromi/Tbc1d32bromi (more )
Structure Level Pattern Image Note
TS17: neural tube Absent 3B FoxA2 bromi

Specimen 3B FoxA2 Gli2: embryonic day 10.5; Gli2tm1Alj/Gli2tm1Alj (more )
Structure Level Pattern Image Note
TS17: neural tube Absent 3B FoxA2 Gli2

Specimen 3B FoxA2 bromi,Gli2: embryonic day 10.5; Gli2tm1Alj/Gli2tm1Alj, Tbc1d32bromi/Tbc1d32bromi (more )
Structure Level Pattern Image Note
TS17: neural tube Absent 3B FoxA2 bromi,Gli2

Specimen S2C FoxA2 WT: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: neural tube Present Regionally restricted S2C FoxA2 WT

Specimen S2C FoxA2 bromi: embryonic day 10.5; Tbc1d32bromi/Tbc1d32bromi (more )
Structure Level Pattern Image Note
TS17: neural tube Absent S2C FoxA2 bromi

Specimen S2C FoxA2 Rab23opb2: embryonic day 10.5; Rab23opb2/Rab23opb2 (more )
Structure Level Pattern Image Note
TS17: neural tube Present Regionally restricted S2C FoxA2 Rab23opb2 Expression domain shifted compared to wild type.

Specimen S2C FoxA2 bromi,Rab23opb2: embryonic day 10.5; Rab23opb2/Rab23opb2, Tbc1d32bromi/Tbc1d32bromi (more )
Structure Level Pattern Image Note
TS17: neural tube Absent S2C FoxA2 bromi,Rab23opb2 Authors report same dorsalized phenotype as in bromi single mutants.

Specimen S4B FoxA2 WT: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: neural tube floor plate Present S4B FoxA2 WT

Specimen S4B FoxA2 RRF/RRF: embryonic day 10.5; Tbc1d32Gt(RRF165)Byg/Tbc1d32Gt(RRF165)Byg (more )
Structure Level Pattern Image Note
TS17: neural tube Absent S4B FoxA2 RRF/RRF Expression identical to that of bromi mutants.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory